A study of JNJ-95475939 in the treatment of participants with moderate to severe atopic dermatitis

This study is looking for adult volunteers, aged 18 or older, who have moderate to severe eczema. Your eczema needs to have started at least a year ago and be affecting a noticeable part of your body (at least 10%). Also, your skin condition will be checked using specific scores to make sure it's moderate to severe at the start of the study, and your itching needs to be at a certain level.

You might be suitable if previous treatments, like creams or other medications, haven't worked well enough for you. You also need to be regularly using moisturiser.

However, you won't be able to join if you've previously had a poor response or serious side effects to similar types of eczema medications (like dupilumab, lebrikizumab, or tralokinumab). Pregnant or breastfeeding individuals, or those planning to become pregnant, cannot take part. If you have other significant skin infections or serious underlying health conditions, you might also not be eligible.

If you join this study, it will last for a total of up to 41 weeks. There are three main parts:

First, there's a 'screening period' of up to 5 weeks. During this time, you'll have checks to see if you're suitable for the study. If you are, you'll move to the next stage.

Then comes the 'treatment period' which lasts up to 24 weeks. You'll be placed into one of five groups by chance, like drawing numbers from a hat. This means you might receive the new medicine (JNJ-95475939) in one of three different doses, an existing medicine (dupilumab), or a dummy treatment (placebo) for the first 12 weeks, before switching to the new medicine for the remaining 12 weeks. All study medicines are given as an injection just under the skin.

Finally, there's a 'follow-up period' of up to 12 weeks. During this time, you won't receive the study medicine, but the team will monitor your health. Throughout the study, you'll have regular checks like physical exams, weight measurements, blood pressure, heart checks (ECG), blood tests, and pregnancy tests (if applicable) to make sure you're safe and to track any changes.