MICROBIOTA AND BLADDER CANCER
Bladder cancer is a common cancer, especially in older men who smoke. However, scientists believe other factors, like the tiny living organisms (microbes) found in our bodies, might also be important. This study focuses on microbes in the bladder. While we know microbes exist in healthy people, researchers want to see if specific changes in these bladder microbes are connected to bladder cancer. They will be taking small samples from both healthy and cancerous parts of the bladder in the same patient to look closely at these microbial differences. The aim is to understand if certain bacteria or viruses could be involved in causing bladder cancer, which might help lead to new ways to prevent or treat it.
En un coup d'œil
De quoi parle cette étude ?
Bladder cancer is a type of cancer that affects the bladder, an organ that stores urine. In the UK, it's a condition that mostly affects older men, and smoking is a well-known risk factor. However, researchers are exploring other things that might contribute to bladder cancer, and one area of interest is the "microbiota" – that's the community of tiny living organisms, like bacteria and viruses, that live in and on our bodies.
Recently, scientists have learned that there are indeed microbes in the bladder, even in healthy people. We already know that changes in microbes in other parts of the body, like the gut, can be linked to certain diseases. So, this study wants to see if changes in the microbes found in bladder tissue might also be connected to bladder cancer. Previous small studies have hinted that there might be differences in the types of microbes found in cancerous bladder tissue compared to healthy bladder tissue.
The team conducting this study wants to confirm these early findings with a larger, more detailed investigation. They will carefully compare the microbes in cancerous bladder tissue with those in healthy bladder tissue from the same patient. By doing this, they hope to identify any specific bacteria or viruses that might be linked to bladder cancer. Understanding these microbial connections could open doors to new ways of understanding, preventing, or even treating bladder cancer in the future.
Points clés
- This study explores the link between bladder microbes and bladder cancer.
- It aims to compare microbes in cancerous and healthy bladder tissue.
- Participation involves providing tissue samples during planned surgery.
- It's for men aged 18+ suspected of having bladder cancer.
- The research helps doctors better understand bladder cancer causes.
Qui peut être éligible ?
This study is particularly looking for men aged 18 or older who are having their first keyhole surgery (called RTUV) because doctors suspect they might have bladder cancer. You'd also need to be part of the social security scheme and be able to give your full written permission to take part.
There are certain reasons why you wouldn't be able to join. For example, if you've taken antibiotics recently (within the last three months) or if you currently have a urine infection. Also, if you've had surgery on your bladder or genitals in the past six months, or if you've previously had radiotherapy to your pelvis, you wouldn't be eligible.
Other reasons for not being able to join include having a long-term catheter, a condition called interstitial cystitis, or if your doctors confirm you have a non-cancerous growth after your biopsy. Vulnerable individuals, such as minors or those under legal guardianship, are also not able to participate in this study.
Cet étude pourrait-elle vous convenir ?
Répondez à ces questions rapides pour voir si vous êtes éligible. Ceci est un guide uniquement — l'équipe de recherche prend la décision finale.
- Are you a man aged 18 or older?
- Are you scheduled for your first keyhole bladder surgery (RTUV) for suspected bladder cancer?
- Have you *not* taken antibiotics in the last 3 months?
- Do you *not* currently have a urine infection?
En quoi consiste la participation ?
If you decide to take part in this study, you will be asked to provide a small tissue sample. This sample will be taken during the keyhole bladder surgery (RTUV) you are already scheduled to have. The doctors will take a sample from the area where cancer is suspected and also a sample from healthy bladder tissue nearby. There are no extra procedures or medications involved specifically for the study. Your involvement will mainly be providing these tissue samples for analysis. There are no additional hospital visits required beyond your standard medical care. The total duration of your participation would be limited to the time of your surgery and the analysis of the samples, with no long-term follow-up specifically for the study.
Risques et avantages potentiels
Emplacements (8)
- Cannes HospitalCode postal vérifiéCannes, France· Pas encore en recrutement
- Marseille university HospitalCode postal vérifiéMarseille, France· Pas encore en recrutement
- Menton HospitalCode postal vérifiéMenton, France· Pas encore en recrutement
- Nice University HospitalCode postal vérifiéNice, France· Recrutement
- Nimes University hospitalCode postal vérifiéNîmes, France· Pas encore en recrutement
- Paris University HospitalCode postal vérifiéParis, France· Pas encore en recrutement
- Centre Hospitalier Universitaire de RennesCode postal vérifiéRennes, France· Pas encore en recrutement
- Tours University HospitalCode postal vérifiéTours, France· Pas encore en recrutement
Questions fréquentes
What is the 'microbiota'?
The microbiota is the community of tiny living things, like bacteria and viruses, that live naturally in and on our bodies.
Why is this study only for men?
Bladder cancer is much more common in men, especially older men, so this study is focusing on this group to understand specific factors related to them.
Will taking part change my bladder cancer treatment?
No, taking part in this study will not change the standard medical care or treatment you receive for your bladder cancer.
What is a 'biopsy'?
A biopsy is when doctors take a tiny piece of tissue from your body to examine it more closely under a microscope.
Do I have to take part?
No, taking part is completely voluntary. Your decision will not affect your medical care in any way.
Comment en savoir plus
Alice GAUDART
Parlez toujours à votre médecin généraliste ou spécialiste avant de décider de participer à une étude.
Intéressé à participer ?
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Propulsé par notre forum à community.patient.info. Veuillez être respectueux — ceci n'est pas un avis médical.