Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome

This study is looking for people aged between 5 and 30 years old who have been diagnosed with Prader-Willi syndrome (PWS) through genetic testing. A key part of the study is that participants must have significant hyperphagia, meaning a strong, constant feeling of hunger that leads to seeking out food.

To join, you'll need to live with a caregiver who understands the study and can help you follow the study's instructions and attend appointments. There are also some health conditions or situations that would prevent someone from joining, such as certain heart, kidney, or liver problems, or having had certain recent surgeries. You also can't have other specific genetic conditions or be using certain medications that might interfere with the study, like some other nasal sprays.

Before you can officially join, the study doctors will do a thorough check to make sure it's safe and appropriate for you.

If you decide to take part in this study, you would be involved for about 12 weeks, plus some screening appointments beforehand. During the study, you'd be asked to use a nasal spray three times a day. You wouldn't know if it's the active medicine or a dummy spray, and neither would your doctor. You'd also need to attend several study visits where the team would do health checks, ask questions about your hunger and overall well-being, and collect information. These visits are important for monitoring your health and seeing how the spray might be affecting you. You'd also need to avoid using other nasal sprays or certain medications for the duration of the study.