A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to < 12 Years Old) With Nonsegmental Vitiligo

To join this study, children need to be between 6 and 11 years old and have a specific type of vitiligo called nonsegmental vitiligo. They need to have a certain amount of white patches on their face and body, but not too much overall. There also needs to be some coloured hair within the white patches on their face.

There are also some reasons why a child might not be able to join. For example, if they have other types of vitiligo or other skin conditions that could look similar. Children who have recently used other vitiligo treatments, or who have certain other health issues or serious illnesses, might not be suitable. Also, if a child's weight is very low or very high for their age, they would not be able to participate. It's important that any child joining the study can follow the study instructions and attend all appointments.

If your child takes part, they will receive either the ruxolitinib cream or a cream without the active medicine (the 'vehicle cream') to apply to their skin. The study will involve regular visits to the clinic where doctors and nurses will check your child's skin, look for changes in the white patches, and ask about how they are feeling. They will also carry out assessments to monitor your child's general health.

During the study, your child will need to stop using any other treatments for vitiligo. You will be given clear instructions on how and when to apply the cream. There will also be a follow-up period after your child finishes using the cream to make sure they are still well. The total length of time your child will be involved in the study, including all visits and the follow-up, will be explained in full detail by the study team.