An Observational Study of Patients With Moderate Parkinson's Disease

To join this study, you need to be a man or woman between 50 and 68 years old. You must have been formally diagnosed with Parkinson's disease, specifically a moderate form that has been present for more than 5 years but no longer than 12 years.

Your Parkinson's symptoms should not be fully controlled by your current medicines, meaning you experience both 'on' periods (when medicine works well) and 'off' periods (when symptoms return more strongly). Importantly, doctors should also believe you might be suitable for a special cell therapy treatment in the future, and expect you to live for more than 7 more years.

There are also reasons why you might not be able to join. For example, if your Parkinson's is thought to be caused by something else, or if you have severe uncontrollable movements (dyskinesia) from your medication. The study also cannot include people with severe memory problems, serious mental health conditions like severe depression or psychosis, or other major illnesses that might make it unsafe to participate.

If you decide to take part, your involvement will last anywhere from 3 months up to 2 years. During this time, you will have regular visits to a clinic. At these visits, a study doctor or nurse will check your Parkinson's symptoms using various assessments. You’ll continue to take your usual Parkinson's medications, but the study doctor might suggest some changes to them if they think it would help your symptoms.

At a minimum of two of your clinic visits, you will be asked to undergo what are called 'off-assessments'. This means your symptoms will be evaluated when your medication is not fully active, which helps doctors understand the full range of your Parkinson's. Throughout the study, the team will monitor your health and how your Parkinson's symptoms are changing.