Prophylactic Prostatectomy for Prostate Cancer (PPPC)
Prostate cancer is common in the UK and can be very serious. Many cases are linked to genetics, like having a faulty BRCA2 gene. We know that similar preventive surgeries effectively reduce cancer risk for women with genetic predispositions. However, for men at high genetic risk of prostate cancer, we don't yet know if a preventive operation (prostatectomy) would be beneficial or acceptable. This study aims to understand what men think about this potential surgery. We want to hear from different people, including those with a higher genetic risk or a strong family history of prostate cancer. By talking to people, we hope to learn about their concerns, what information they would need, and what support would be helpful if such an operation were offered in the future.
En un coup d'œil
De quoi parle cette étude ?
Prostate cancer is a serious illness affecting many men in the UK. Sadly, around 12,000 men die from it every year. We know that genetics play a big part in about half of these cases. Some men have specific genetic changes, like those in the BRCA2 gene, which significantly increase their risk of developing prostate cancer, sometimes in a more aggressive form.
For conditions like breast and ovarian cancer, women with certain genetic risks can choose to have preventive operations, like removing their breasts or ovaries, which have been shown to save lives. Currently, we don't have similar options or clear evidence for men at high genetic risk of prostate cancer. However, men with genetic risks often ask their doctors about this possibility. In the future, researchers are considering whether a preventive operation to remove the prostate (called a prophylactic prostatectomy) could be helpful for men identified as having a particularly high genetic risk.
Before even considering offering such an operation, it's really important to understand what men think about it. This study is taking the first step by talking to people to find out if they would consider a preventive prostatectomy. We want to know what concerns they would have, what kind of information they would need, and what support would help them make such a big decision. This surgery, like any operation, has potential side effects, including impacts on sexual function and bladder control. Your opinions are crucial to help us understand if this is a path worth exploring further.
Points clés
- Prostate cancer is common and serious in UK men.
- Genetic factors increase risk for many, including BRCA2 gene carriers.
- This study explores men's views on a potential preventive prostatectomy.
- We need to understand concerns and support needs for this type of surgery.
- Your opinions can help shape future prostate cancer prevention research.
- Participation involves a single, confidential interview.
Qui peut être éligible ?
We are looking for a wide range of people to share their thoughts and experiences. You must be 18 years old or older to take part.
We are especially interested in hearing from men who might be at a higher risk of prostate cancer. This includes those who have a known genetic fault, like in the BRCA2 gene, or a strong family history of prostate cancer. We also particularly want to hear from men of Black African or Black Caribbean background, as they have a higher risk of developing prostate cancer.
Additionally, we welcome men who have already had their prostate removed because of prostate cancer. And importantly, we also want to hear from men whose risk of prostate cancer is not known, or who have the average risk. The only reason you might not be able to take part is if your medical team feels it's not appropriate due to your general health at the moment.
Cet étude pourrait-elle vous convenir ?
Répondez à ces questions rapides pour voir si vous êtes éligible. Ceci est un guide uniquement — l'équipe de recherche prend la décision finale.
- Are you 18 years old or over?
- Are you interested in discussing preventive prostate surgery?
- Do you have a higher genetic risk of prostate cancer, or a strong family history?
- Are you of Black African or Black Caribbean ancestry?
- Have you had prostate surgery for cancer in the past?
- Is your medical team happy for you to take part?
En quoi consiste la participation ?
If you decide to take part in this study, you will have one interview. This will be a 'semi-structured' interview, which means there's a guide of topics we want to cover, but it also allows for open discussion about your views and feelings. The interview will focus on your thoughts and feelings about the idea of a preventive prostatectomy.
We expect the interview to last for about an hour to an hour and a half. It will be conducted at a time and place convenient for you, and could potentially be done virtually. There are no medications, extra hospital visits, or follow-up appointments required beyond this single interview. You will not need to undergo any medical procedures as part of this study. The total time commitment for you would be just the duration of this one interview.
Risques et avantages potentiels
Emplacements (1)
- La Royal Marsden NHS Foundation TrustCode postal vérifiéLondres, Royaume-Uni
Questions fréquentes
What is a 'prophylactic prostatectomy'?
It means having your prostate gland removed to prevent prostate cancer from developing, rather than treating existing cancer.
Will this study offer me a prostatectomy?
No, this study is a pilot project to gather opinions. It will not offer any surgery or medical treatment.
Who is eligible to take part?
We are inviting men aged 18 and over, interested in prostate cancer, including those with higher genetic risk, family history, or of Black African/Caribbean ancestry. We also want to hear from other men, and those who have had previous prostate cancer surgery.
What will I have to do if I participate?
You will take part in a single, relaxed interview lasting about 60-90 minutes, where you will share your thoughts and feelings about preventive prostate surgery.
Mes informations personnelles seront-elles gardées privées ?
Yes, all your responses and personal information will be kept confidential and anonymised to protect your privacy.
Comment en savoir plus
Parlez toujours à votre médecin généraliste ou spécialiste avant de décider de participer à une étude.
Intéressé à participer ?
Discussion
Discussion communautaire
Propulsé par notre forum à community.patient.info. Veuillez être respectueux — ceci n'est pas un avis médical.