Can I take Atorvastatin and Pyridostigmine together?
Drug interaction guide
Originally published 25 Jan 2026
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There is a potential for increased muscle-related side effects when taking these two medicines together. Both drugs can independently affect muscle function; atorvastatin can cause muscle aches or weakness (myopathy), and pyridostigmine is used to treat muscle weakness in conditions like myasthenia gravis. Taking them together might make it harder to tell if muscle symptoms are due to your condition or a side effect of the statin.
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Why this happens
This is a pharmacodynamic interaction. Atorvastatin can occasionally cause muscle damage or inflammation. Pyridostigmine works by increasing levels of a chemical (acetylcholine) to help muscles contract. While they don't interfere with how the body breaks each drug down, their combined effects on muscle tissue may increase the risk of muscle pain or weakness.
What you should do
You can usually take these medicines together, but you should be extra vigilant. Report any new or worsening muscle pain, tenderness, or weakness to your doctor immediately, especially if you also feel generally unwell or have a fever. Your doctor may want to monitor your muscle enzyme levels (CK levels) via a blood test.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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