Can I take Losartan and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Why this happens
Losartan is a blood pressure medication (angiotensin II receptor blocker) and vitamin D is a fat-soluble vitamin. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.
What you should do
You can continue to take both as prescribed. It is always a good idea to have your blood pressure and kidney function monitored regularly by your doctor while taking losartan, regardless of vitamin D use.
Important precautions
Pregnancy
You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.
Hypercalcaemia (high blood calcium)
Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.
Potassium-rich foods (e.g., bananas, spinach, salt substitutes)
Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.
High-fat meals
Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Mounjaro and Insulin together?
Taking Mounjaro (tirzepatide) and insulin together significantly increases your risk of having a 'hypo' (hypoglycaemia), which is when your blood sugar levels drop too low. Symptoms of a hypo can include feeling shaky, sweaty, dizzy, hungry, or confused. In severe cases, it can be dangerous.

Drug interactions checker
Can I take Ashwagandha and Vitamin B12 together?
There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Adcal-D3 and Carbocisteine together?
- Can I take Alogliptin and Fibre supplements together?
- Can I take Amlodipine and Losartan together?
- Can I take Ashwagandha and Oestrogel pump-pack together?
- Can I take Aspirin and Diclofenac together?
- Can I take Atenolol and Ramipril together?
- Can I take Bisoprolol and Fibre supplements together?
- Can I take Candesartan and Rosuvastatin together?
- Can I take CBD oil and Clozapine together?
- Can I take Co-codamol and Mirtazapine together?
- Can I take Cordyceps and Shiitake together?
- Can I take Danazol and Naproxen together?
- Can I take Dextromethorphan cough medicines and Sertraline together?
- Can I take Glucosamine and Vitamin B12 together?
- Can I take Levothyroxine and Losartan together?
- Can I take Magnesium and Ramipril together?
- Can I take Naproxen and Pregabalin together?
- Can I take Paracetamol and Ibuprofen together?
- Can I take Vitamin B complex and Vitamin D together?