integrin subunit beta 3
Dernière mise à jour 18 Aug 2020
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. Platelets circulate in blood and are an essential component of blood clots. The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet.
Normal function
La ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. Platelets circulate in blood and are an essential component of blood clots. The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet.
During clot formation, integrin αIIbβ3 binds to a protein called fibrinogen. Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. Blood clots protect the body after injury by sealing off damaged blood vessels and preventing further blood loss. Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing.
Conditions referring to this gene or chromosome
Other names
beta 3 integrin
CD61
GP3A
GPIIIa
integrin beta 3
integrin beta-3 precursor
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
platelet glycoprotein IIIa
platelet GPIIIa
platelet membrane glycoprotein IIIa
vitronectin receptor beta chain
Related patient information and medicines
Patient information leaflet
Puis-je prendre Lansoprazole et Mirabegron ensemble ?
There are no known significant interactions between lansopra... It is generally considered safe to take these two medications together. Why this happens Lansoprazole is a proton pump inhibitor used to reduce stomach acid, while mirabegron is a beta-3 adrenergic agonist used for overactive bladder. They are processed by different pathways in the.
Patient information leaflet
Puis-je prendre Atorvastatine et Bisoprolol ensemble ?
Pourquoi cela se produit Atorvastatin is a statin used to lower cholesterol, and bisoprolol is a beta-blocker used to manage blood pressure and heart rate. They are processed by different pathways in the body and do ... Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to.
Patient information leaflet
Puis-je prendre Alogliptine et Bisoprolol ensemble ?
It can also slightly increase the risk of your blood suga... Why this happens Bisoprolol is a beta-blocker. These medicines can mask the physical symptoms of low blood sugar, such as a fast heartbeat or tremors. Our Vérificateur d'Interactions Médicamenteuses helps you check whether votre prescriptions, over-the-counter medicines, and supplements are safe to.
Patient information leaflet
Puis-je prendre Allopurinol et Co-amoxiclav ensemble ?
Taking allopurinol and co-amoxiclav together increases the risk of developing a skin rash. While most rashes are mild, there is a... Penicillin allergy Do not take co-amoxiclav if you have ever had a severe allergic reaction (such as anaphylaxie or a skin rash) à pénicilline or any other 'beta-lactam' antibiotic, as this can be fatal. Disclaimer.
Patient information leaflet
Puis-je prendre Bisoprolol et Trimbow ensemble ?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Why this happens Bisoprolol est a 'beta-blocker' and formoterol (in Trimbow) is a 'beta-agonist'. Important precautions Acute breathing distress Bisoprolol est a beta-blocker and can cause narrowing of the airways, potentially triggering a severe asthma attack.
Patient information leaflet
Puis-je prendre Bisoprolol et Metformine ensemble ?
It may also slightly change how your body manages blood sugar levels, potentially making metformin less effective or inc... Why this happens Bisoprolol est a beta-blocker. It works by slowing the heart rate and blocking certain stress hormones. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Lectures complémentaires et références
- integrin subunit beta 3; MedlinePlus, National Library of Medicine.
- Kobayashi Y, Matsui H, Kanai A, Tsumura M, Okada S, Miki M, Nakamura K, Kunishima S, Inaba T, Kobayashi M. Identification of the integrin beta3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis. Br J Haematol. 2013 Feb;160(4):521-9. doi: 10.1111/bjh.12160. Epub 2012 Dec 17.
- Nurden AT, Fiore M, Nurden P, Pillois X. Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood. 2011 Dec 1;118(23):5996-6005. doi: 10.1182/blood-2011-07-365635. Epub 2011 Sep 13.
- Nurden AT, Pillois X, Fiore M, Alessi MC, Bonduel M, Dreyfus M, Goudemand J, Gruel Y, Benabdallah-Guerida S, Latger-Cannard V, Negrier C, Nugent D, Oiron RD, Rand ML, Sie P, Trossaert M, Alberio L, Martins N, Sirvain-Trukniewicz P, Couloux A, Canault M, Fronthroth JP, Fretigny M, Nurden P, Heilig R, Vinciguerra C. Expanding the Mutation Spectrum Affecting alphaIIbbeta3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. Hum Mutat. 2015 May;36(5):548-61. doi: 10.1002/humu.22776.
- Nurden AT, Pillois X, Fiore M, Heilig R, Nurden P. Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the alphaIIbbeta3 integrin. Semin Thromb Hemost. 2011 Sep;37(6):698-706. doi: 10.1055/s-0031-1291380. Epub 2011 Nov 18.
- Pillitteri D, Pilgrimm AK, Kirchmaier CM. Novel Mutations in the GPIIb and GPIIIa Genes in Glanzmann Thrombasthenia. Transfus Med Hemother. 2010;37(5):268-277. doi: 10.1159/000320258. Epub 2010 Sep 15.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.