lysine demethylase 6A
Dernière mise à jour 12 avr. 2023
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La KDM6A gene provides instructions for making an enzyme called lysine-specific demethylase 6A that is found in many organs and tissues of the body. Lysine-specific demethylase 6A functions as a histone demethylase. Histone demethylases are enzymes that modify proteins called histones. Histones are structural proteins that attach (bind) to DNA and give chromosomes their shape. By removing a molecule called a methyl group from histones (a process called demethylation), histone demethylases control (regulate) the activity of certain genes. Lysine-specific demethylase 6A appears to regulate certain genes that are important for development.
Normal function
La KDM6A gene provides instructions for making an enzyme called lysine-specific demethylase 6A that is found in many organs and tissues of the body. Lysine-specific demethylase 6A functions as a histone demethylase. Histone demethylases are enzymes that modify proteins called histones. Histones are structural proteins that attach (bind) to DNA and give chromosomes their shape. By removing a molecule called a methyl group from histones (a process called demethylation), histone demethylases control (regulate) the activity of certain genes. Lysine-specific demethylase 6A appears to regulate certain genes that are important for development.
Lysine-specific demethylase 6A is also believed to act as a tumour suppressor, which means it normally helps prevent cells from growing and dividing in an uncontrolled way.
Conditions referring to this gene or chromosome
Other names
bA386N14.2
bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))
histone demethylase UTX
KABUK2
KDM6A_HUMAN
lysine (K)-specific demethylase 6A
lysine-specific demethylase 6A
ubiquitously transcribed tetratricopeptide repeat protein X-linked
ubiquitously-transcribed TPR gene on the X chromosome
ubiquitously-transcribed TPR protein on the X chromosome
UTX
Related patient information and medicines
Lectures complémentaires et références
- lysine demethylase 6A; MedlinePlus, National Library of Medicine.
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