PNKD metallo-beta-lactamase domain containing
Dernière mise à jour 28 Jun 2022
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
Researchers have not determined the role of the PNKD gene (frequently called the MR1 gene) in the human body. This gene is highly active (expressed) in the brain, which suggests that it plays an important role in normal brain function. The protein produced from the PNKD gene may help control the release of chemicals called neurotransmitters, which allow nerve cells (neurons) to communicate with one another.
Normal function
Researchers have not determined the role of the PNKD gene (frequently called the MR1 gene) in the human body. This gene is highly active (expressed) in the brain, which suggests that it plays an important role in normal brain function. The protein produced from the PNKD gene may help control the release of chemicals called neurotransmitters, which allow nerve cells (neurons) to communicate with one another.
The PNKD protein is similar to another protein that helps break down a chemical called methylglyoxal. Methylglyoxal is found in alcoholic beverages, coffee, tea, and cola. Research has demonstrated that this chemical is toxic to nerve cells (neurons). The PNKD protein may perform a function similar to this protein.
Conditions referring to this gene or chromosome
Other names
brain protein 17
BRP17
DKFZp564N1362
DYT8
FKSG19
FPD1
KIAA1184
KIPP1184
MGC31943
MR-1
MR-1S
MR1
myofibrillogenesis regulator 1
paroxysmal nonkinesigenic dyskinesia
PDC
PKND1
PNKD_HUMAN
Related patient information and medicines
Patient information leaflet
Germes
This leaflet gives a brief overview of the different types of germs (microbes) that can cause infections. What are germs. Another example is some bacteria produce chemicals called enzymes tel que extended-spectrum beta-lactamases (ESBLs) , which make them resistant to some antibiotics. The more antibiotics are used, the greater the problem of.
Patient information leaflet
Puis-je prendre la crinière de lion et le maitake ensemble ?
This means they work in similar ways: both contain compounds (like beta-glucans) that can improve insulin sensitivity and others that may prevent blood platelets from sticking together. Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search.
Patient information leaflet
Puis-je prendre Royal sun et Shiitake ensemble ?
Both Royal Sun (Agaricus blazei) and Shiitake (Lentinula edodes) mushrooms contain high levels of beta-glucans, which are substances that stimulate the immune system. Taking them together may cause your immune system to ... Our Médicaments Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and suppléments are.
Patient information leaflet
Puis-je prendre Reishi et queue de dinde ensemble ?
Combining them might increase the chance of thinning your blood or over-stimulating your immune system, though this is rarely a problem for healthy people. Why this happens Both reishi (Ganoderma lucidum) and turkey tail (Trametes versicolor) contain bioactive compounds called polysaccharides (like beta-glucans) that modulate the immune system..
Patient information leaflet
Puis-je prendre Reishi et Royal sun ensemble ?
Les deux Reishi and Royal Sun (Agaricus blazei) mushrooms can thin the blood and lower blood sugar levels. Consuming high amounts of caffeine may counteract the intende... General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). For the best absorption, it is often recommended to take them on an empty stomach, at.
Patient information leaflet
Puis-je prendre Royal sun et White button ensemble ?
Les deux Royal Sun (Agaricus blazei) et White Button mushrooms contain compounds that may lower blood sugar levels. Taking them together could potentially cause your blood sugar to drop too low (hypoglycaemia). General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). Our Vérificateur d'Interactions Médicamenteuses helps you.
Lectures complémentaires et références
- PNKD metallo-beta-lactamase domain containing; MedlinePlus, National Library of Medicine.
- Bruno MK, Lee HY, Auburger GW, Friedman A, Nielsen JE, Lang AE, Bertini E, Van Bogaert P, Averyanov Y, Hallett M, Gwinn-Hardy K, Sorenson B, Pandolfo M, Kwiecinski H, Servidei S, Fu YH, Ptacek L. Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia. Neurology. 2007 May 22;68(21):1782-9. doi: 10.1212/01.wnl.0000262029.91552.e0.
- Chen DH, Matsushita M, Rainier S, Meaney B, Tisch L, Feleke A, Wolff J, Lipe H, Fink J, Bird TD, Raskind WH. Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds. Arch Neurol. 2005 Apr;62(4):597-600. doi: 10.1001/archneur.62.4.597.
- Gardiner AR, Jaffer F, Dale RC, Labrum R, Erro R, Meyer E, Xiromerisiou G, Stamelou M, Walker M, Kullmann D, Warner T, Jarman P, Hanna M, Kurian MA, Bhatia KP, Houlden H. The clinical and genetic heterogeneity of paroxysmal dyskinesias. Brain. 2015 Dec;138(Pt 12):3567-80. doi: 10.1093/brain/awv310. Epub 2015 Nov 23.
- Lee HY, Xu Y, Huang Y, Ahn AH, Auburger GW, Pandolfo M, Kwiecinski H, Grimes DA, Lang AE, Nielsen JE, Averyanov Y, Servidei S, Friedman A, Van Bogaert P, Abramowicz MJ, Bruno MK, Sorensen BF, Tang L, Fu YH, Ptacek LJ. The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Hum Mol Genet. 2004 Dec 15;13(24):3161-70. doi: 10.1093/hmg/ddh330. Epub 2004 Oct 20.
- Rainier S, Thomas D, Tokarz D, Ming L, Bui M, Plein E, Zhao X, Lemons R, Albin R, Delaney C, Alvarado D, Fink JK. Myofibrillogenesis regulator 1 gene mutations cause paroxysmal dystonic choreoathetosis. Arch Neurol. 2004 Jul;61(7):1025-9. doi: 10.1001/archneur.61.7.1025.
- Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptacek LJ. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2935-41. doi: 10.1073/pnas.1501364112. Epub 2015 Feb 17.
- Shen Y, Lee HY, Rawson J, Ojha S, Babbitt P, Fu YH, Ptacek LJ. Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability. Hum Mol Genet. 2011 Jun 15;20(12):2322-32. doi: 10.1093/hmg/ddr125. Epub 2011 Apr 12.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.