Can I take Reishi and Turkey tail together?

Why this happens

Both reishi (Ganoderma lucidum) and turkey tail (Trametes versicolor) contain bioactive compounds called polysaccharides (like beta-glucans) that modulate the immune system. They also both possess mild antiplatelet properties, meaning they can slow down how quickly your blood clots. Taking them together creates an additive effect, where the two supplements work in the same way to enhance these actions.

How to know if you're having a drug interaction

You may be experiencing an interaction between reishi and turkey tail if:

• You develop digestive symptoms, such as bloating, nausea, diarrhoea, or stomach discomfort.

• You feel unusually tired, dizzy, or lightheaded after taking both supplements together.

• You notice headaches or flu-like symptoms, which may be linked to immune stimulation.

• You experience allergic-type reactions, such as itching, rash, or swelling.

• You have increased bruising or bleeding, particularly if you also take blood-thinning medicines.

• Symptoms start after beginning or increasing the dose of either supplement.
  

What you should do

It is usually fine to take these together, but you should speak to your doctor first if you are scheduled for surgery, take blood-thinning medication (like warfarin or aspirin), or have an autoimmune condition. Stop taking both at least two weeks before any planned surgical procedures to avoid excess bleeding. If you have any of the above symptoms, you should:

• Stop taking the supplements and monitor whether symptoms improve.

• Speak to your GP or pharmacist for advice, especially if symptoms persist.

• Seek urgent medical help if you develop severe allergic symptoms, such as swelling of the face or difficulty breathing.

• Tell your healthcare professional about all medicines and supplements you are taking.

• Avoid restarting the supplements until you have been advised it is safe to do so.

Important precautions

Bleeding disorders or surgery

These supplements may slow blood clotting and increase the risk of bleeding. You must stop taking these at least 2 weeks before any scheduled surgery. Use with caution if you are taking blood-thinning medications like warfarin or aspirin.

Diabetes

These supplements can lower blood sugar levels. If you are taking insulin or other diabetes medications, monitor your blood sugar closely as your dose may need adjustment to prevent hypoglycaemia (dangerously low blood sugar).

Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)

These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.

Low blood pressure (Hypotension)

Reishi may lower blood pressure. If you already have low blood pressure or take medication to control high blood pressure, they could cause your blood pressure to drop too low.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking medicinal mushrooms. Both alcohol and certain compounds in these mushrooms are processed by the liver; combining them may increase the strain on your liver or alter how the supplements are metabolised.

Caffeine

Reishi is often used for its calming effects, while caffeine is a stimulant. Consuming high amounts of caffeine may counteract the intended relaxing effects of the supplement.

General Food Intake

These medicinal mushrooms contain complex polysaccharides (beta-glucans). For the best absorption, it is often recommended to take them on an empty stomach, at least 30 minutes before a meal, or with a small amount of Vitamin C (such as a small glass of orange juice) which may help the body absorb the active compounds.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.