Can I take Clarithromycin and Ibuprofen together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no direct interaction between clarithromycin and ibuprofen that would prevent them from being taken together. However, both medications can occasionally cause stomach upset or irritation. Taking them at the same time might increase the chance of experiencing nausea, indigestion, or stomach pain. Additionally, if you are taking clarithromycin for a severe infection, your doctor may advise you to avoid ibuprofen if there are concerns about your kidney function or hydration levels.
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Why this happens
Clarithromycin is an antibiotic and ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). They do not significantly interfere with how the body processes (metabolises) each other. The main concern is a 'pharmacodynamic' one, where both drugs have the potential to irritate the lining of the stomach or put slight stress on the kidneys, though this is rarely a problem for healthy individuals.
What you should do
It is generally safe to take these two medicines together. To protect your stomach, try to take both the clarithromycin and the ibuprofen with food or a milky drink. If you develop severe stomach pain, persistent vomiting, or if you feel very dehydrated, stop taking the ibuprofen and speak to your doctor or pharmacist. Always complete the full course of your antibiotic.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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