Can I take Amitriptyline and Quinine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amitriptyline and quinine together can increase the risk of developing a serious heart rhythm problem. This can cause symptoms like a racing heart, dizziness, or fainting.
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Why this happens
Both amitriptyline and quinine can affect the electrical activity of the heart (specifically by prolonging the 'QT interval'). When used together, this effect is added together, making it more likely that the heart's rhythm will become unstable. Additionally, quinine may slow down how quickly the liver breaks down amitriptyline, leading to higher levels of the medicine in your blood.
What you should do
You should speak to your doctor before taking these two medicines together. They may want to check your heart rhythm with an ECG (heart trace) or consider an alternative treatment for leg cramps or depression. If you are already taking both and feel dizzy, faint, or notice your heart beating very fast or irregularly, seek medical help immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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