Can I take Glucosamine and Vitamin C together?

Why this happens

Glucosamine is a building block for cartilage, while vitamin C is essential for the body to produce collagen, the protein that holds joints together. They work through different pathways in the body and do not interfere with how the other is absorbed, broken down, or excreted.

What you should do

It is generally safe to take glucosamine and vitamin C at the same time. Always follow the dosage instructions on the product packaging and inform your doctor or pharmacist about any supplements you are taking, especially if you have diabetes or are taking blood-thinning medication like warfarin.

Important precautions

Shellfish allergy

Many glucosamine supplements are derived from the shells of crustaceans. If you have a shellfish allergy, you must check the label for a shellfish-free (vegetarian) version to avoid a serious allergic reaction. Vegan or shellfish-free versions are available.

Asthma

Glucosamine may worsen asthma symptoms or cause increased wheezing. If your asthma symptoms become harder to control after starting this supplement, you should stop taking it immediately.

Diabetes

Glucosamine is an amino sugar and may affect your blood glucose levels. You should monitor your blood sugar more closely when starting or changing your dose.

Taking Warfarin (blood thinner)

Glucosamine can significantly increase the blood-thinning effect of warfarin, which increases your risk of serious bleeding. Do not take glucosamine with warfarin unless specifically monitored by your doctor.

Kidney stones (oxalate)

High doses of Vitamin C (typically over 1000mg daily) can increase the amount of oxalate in your urine, significantly raising the risk of developing kidney stones if you are prone to them.

G6PD deficiency

If you have glucose-6-phosphate dehydrogenase (G6PD) deficiency, high doses of vitamin C can cause your red blood cells to break down (haemolysis).

Haemochromatosis

Vitamin C increases the absorption of iron from your food. If you have an iron-overload disorder like haemochromatosis, you should avoid high-dose supplements.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while using glucosamine. While there is no direct interaction, alcohol can contribute to inflammation or stomach irritation, which may counteract the benefits of the supplement.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.