Can I take Mirtazapine and Pregabalin together?

Pourquoi cela se produit

Both medicines work by slowing down activity in the central nervous system (the brain and nerves). When taken together, their sedative effects add up, leading to a stronger effect than either drug would have on its own.

Use this combination with caution. Avoid driving or operating heavy machinery until you know how these medicines affect you. Do not drink alcohol while taking these, as it will make the sleepiness much worse. If you feel extremely drowsy or have trouble breathing, contact your doctor immediately.

Suicidal thoughts and self-harm

Antidepressants and medicines for nerve pain can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Monitor your mood closely and seek urgent medical help if you experience any distressing thoughts.

Drug dependence and addiction

Pregabalin is a controlled drug because it carries a risk of dependence and addiction. You must only take the dose prescribed and should not stop taking it suddenly, as this can cause severe withdrawal symptoms.

Syndrome sérotoninergique

When taken with other serotonergic medicines, mirtazapine can cause a life-threatening condition called serotonin syndrome. Seek immediate medical attention if you experience high fever, agitation, shivering, or severe muscle twitching.

Agranulocytosis (low white blood cells)

La mirtazapine peut rarement provoquer une chute grave du nombre de globules blancs. Vous devez contacter un médecin immédiatement si vous développez des signes d'infection, tels qu'une fièvre élevée, un mal de gorge sévère ou des ulcères buccaux.

Alcool

It is best to avoid or strictly limit alcohol while taking these medicines. Both mirtazapine and pregabalin cause drowsiness and dizziness; alcohol significantly increases these effects, which can lead to dangerous levels of sedation, impaired coordination, and an increased risk of falls or accidents. Combining them also increases the risk of respiratory depression (slowed breathing).

Caféine (Café, Thé, Boissons Énergisantes)

Mirtazapine is often prescribed to help with sleep and anxiety. Caffeine is a stimulant that can counteract the sedative effects of mirtazapine, potentially making your treatment less effective or increasing feelings of restlessness and anxiety.

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Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.