Can I take Ramipril and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking ramipril and sertraline together can occasionally cause the level of sodium in your blood to drop too low (a condition called hyponatraemia). This can make you feel tired, confused, or dizzy, and in rare cases, it can be serious. Additionally, both medicines can slightly increase the risk of bleeding, particularly in the stomach.
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Why this happens
Both ramipril (an ACE inhibitor) and sertraline (an SSRI antidepressant) are known to independently cause the body to retain water and lose sodium. When used together, this effect is added together. Furthermore, sertraline affects how platelets (cells that help blood clot) work, while ramipril can sometimes affect blood vessels, slightly increasing the chance of bruising or bleeding.
What you should do
It is generally safe to take these together, but you should be aware of the symptoms of low sodium. Contact your doctor if you experience unusual tiredness, confusion, muscle weakness, or persistent headaches. Your doctor may want to perform a simple blood test to check your sodium levels shortly after you start taking both medicines. You should also report any unusual bruising or dark, tarry stools to your GP.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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