Puis-je prendre le Méthotrexate et l'Ibuprofène ensemble ?

Pourquoi cela se produit

Methotrexate is cleared from your body through the kidneys. Ibuprofen interferes with this process in two ways: it reduces blood flow to the kidneys and blocks the specific 'pumps' the kidneys use to flush methotrexate out. This causes the methotrexate to build up in your system.

Do not take ibuprofen (or other similar anti-inflammatory drugs like naproxen or aspirin) while taking methotrexate unless your specialist doctor has specifically told you to do so and is monitoring your blood tests closely. For pain relief, paracetamol is usually a safer alternative. If you have already taken both and feel unwell, or develop a sore throat, fever, or unusual bruising, contact your doctor immediately.

Drug Interaction (Kidney/Blood)

Do not take ibuprofen while taking methotrexate unless specifically directed by your specialist. Ibuprofen can stop methotrexate from leaving your body, leading to a dangerous build-up and severe toxicity.

Pregnancy and Conception

Le méthotrexate peut provoquer de graves malformations congénitales et des fausses couches. Vous devez utiliser une contraception efficace pendant le traitement et pendant au moins 6 mois après l'arrêt. Cela concerne à la fois les hommes et les femmes.

Infection and Blood Disorders

Methotrexate can suppress your immune system and bone marrow. You must seek immediate medical help if you develop a sore throat, fever, mouth ulcers, or unexplained bruising/bleeding.

Ulcères d'estomac ou saignements

Évitez l'ibuprofène si vous avez déjà eu un ulcère à l'estomac, une perforation ou un saignement, car cela peut causer des dommages graves à la muqueuse de l'estomac.

Grossesse (troisième trimestre)

Ne prenez pas d'ibuprofène si vous êtes enceinte de plus de 6 mois, car cela peut provoquer de graves problèmes cardiaques et rénaux chez le bébé à naître ainsi que des complications lors de l'accouchement.

Asthme

Do not take ibuprofen if you have asthma and have ever experienced wheezing, shortness of breath, or a runny nose after taking aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack.

Alcool

You should strictly limit or avoid alcohol while taking methotrexate. Both alcohol and methotrexate can cause liver damage; using them together significantly increases the risk of serious liver toxicity. Your doctor will advise if a very small amount is permissible based on your blood tests.

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

Caféine (Café, Thé, Cola)

High intake of caffeine may reduce the effectiveness of methotrexate for some conditions like rheumatoid arthritis. If you notice your symptoms worsening, try to keep your caffeine intake consistent and moderate.

Produits laitiers

Milk and other dairy products contain an enzyme called xanthine oxidase which can break down methotrexate before it is absorbed. If you are taking methotrexate tablets, it is best to avoid consuming large amounts of dairy at the same time as your dose to ensure you get the full benefit of the medicine.

Nourriture (Général)

It is best to take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduces the chance of indigestion or stomach upset.

Taking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.