Can I take Sertraline and Trazodone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking sertraline and trazodone together increases the risk of a rare but serious condition called serotonin syndrome. This happens when there is too much of a chemical called serotonin in your brain. You may also feel more drowsy, dizzy, or have difficulty concentrating.
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Why this happens
Both sertraline and trazodone increase the levels of serotonin in the brain. When used together, these effects add up (pharmacodynamic interaction), potentially leading to an overload. Additionally, both drugs can have a sedative effect, which is increased when they are combined.
What you should do
You should only take these two medicines together if they have been specifically prescribed by your doctor. Be aware of symptoms of serotonin syndrome, such as shivering, sweating, a very high temperature, fast heartbeat, muscle twitching, or agitation. If you experience these, seek medical help immediately. Avoid driving or using machinery until you know how this combination affects you.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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