Can I take St john's wort and Vitamin d together?
Drug interaction guide
Originally published 25 Jan 2026
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St John's Wort may lower the levels of Vitamin D in your body, potentially leading to a deficiency. This means your Vitamin D supplement might not work as well as it should to support your bone health and immune system.
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Why this happens
St John's Wort is a 'liver enzyme inducer'. It speeds up the proteins (specifically CYP3A4) in your liver that break down medications and vitamins. This causes Vitamin D to be cleared from your system much faster than normal.
What you should do
If you are taking both, you should speak to your GP. They may want to monitor your Vitamin D levels with a blood test or suggest increasing your Vitamin D dose. Do not stop taking prescribed medication without consulting your doctor first.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine

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