Can I take Tizanidine and Trazodone together?
Drug interaction guide
Originally published 25 Jan 2026
Répond aux besoins du patient lignes directrices éditoriales
- TéléchargerTélécharger
- Partager
- Langue
- Discussion
Taking tizanidine and trazodone together can make you feel extremely drowsy, dizzy, or lightheaded. It can also cause a significant drop in your blood pressure, which might lead to fainting or feeling like you are going to pass out. Your breathing may also become slower or shallower.
Dans cet article :
Poursuivre la lecture ci-dessous
Why this happens
Both drugs have a 'sedating' effect on the brain and central nervous system. When used together, these effects add up (additive effect). Additionally, both medications can lower blood pressure—tizanidine by acting on certain receptors in the brain and trazodone as a side effect of its antidepressant action.
What you should do
You should speak to your doctor before taking these two medicines together. If your doctor confirms you need both, they may suggest taking them at different times or starting with a very low dose. Do not drive, cycle, or operate machinery until you know how this combination affects you. Get up slowly from a sitting or lying position to avoid dizziness.
Poursuivre la lecture ci-dessous
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Traitement et médicaments
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.
Traitement et médicaments
Can I take Esomeprazole and Magnesium together?
Taking esomeprazole for a long time (usually more than three months) can lower the levels of magnesium in your blood. This can lead to symptoms like tiredness, muscle spasms, or an irregular heartbeat. Additionally, if you take magnesium as an antacid or supplement at the same time as esomeprazole, it might slightly interfere with how well the medicine is absorbed.
Poursuivre la lecture ci-dessous
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets liés à la santé.
Vous ne vous sentez pas bien ?
Évaluez gratuitement vos symptômes en ligne
Inscrivez-vous à la newsletter destinée aux patients
Votre dose hebdomadaire de conseils santé clairs et fiables, rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.