succinate dehydrogenase complex subunit D
Dernière mise à jour 1 May 2023
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La SDHD gene provides instructions for making one of four subunits of the succinate dehydrogenase (SDH) enzyme. The SDH enzyme plays a critical role in mitochondria, which are structures inside cells that convert the energy from food into a form that cells can use. The SDHD protein helps anchor the SDH enzyme in the mitochondrial membrane.
Normal function
La SDHD gene provides instructions for making one of four subunits of the succinate dehydrogenase (SDH) enzyme. The SDH enzyme plays a critical role in mitochondria, which are structures inside cells that convert the energy from food into a form that cells can use. The SDHD protein helps anchor the SDH enzyme in the mitochondrial membrane.
Within mitochondria, the SDH enzyme links two important pathways in energy conversion: the citric acid cycle (or Krebs cycle) and oxidative phosphorylation. As part of the citric acid cycle, the SDH enzyme converts a compound called succinate to another compound called fumarate. Negatively charged particles called electrons are released during this reaction. The electrons are transferred through the SDH subunits, including the SDHD protein, to the oxidative phosphorylation pathway. In oxidative phosphorylation, the electrons create an electrical charge that provides energy for the production of adenosine triphosphate (ATP), the cell's main energy source.
Succinate, the compound on which the SDH enzyme acts, is an oxygen sensor in the cell and can help turn on specific pathways that stimulate cells to grow in a low-oxygen environment (hypoxia). In particular, succinate stabilizes a protein called hypoxia-inducible factor (HIF) by preventing a reaction that would allow HIF to be broken down. HIF controls several important genes involved in cell division and the formation of new blood vessels in a hypoxic environment.
La SDHD gene is a tumour suppressor, which means it prevents cells from growing and dividing in an uncontrolled way.
Conditions referring to this gene or chromosome
Other names
CBT1
CII-4
cybS
DHSD_HUMAN
PGL
PGL1
QPs3
SDH4
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
succinate dehydrogenase complex subunit D, integral membrane protein
succinate dehydrogenase complex, subunit D, integral membrane protein
succinate dehydrogenase ubiquinone cytochrome B small subunit
succinate-ubiquinone oxidoreductase cytochrome b small subunit
succinate-ubiquinone reductase membrane anchor subunit
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Lectures complémentaires et références
- succinate dehydrogenase complex subunit D; MedlinePlus, National Library of Medicine.
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