Can I take Amitriptyline and Fexofenadine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together may increase the risk of side effects such as a very dry mouth, blurred vision, constipation, or difficulty passing urine. It may also make you feel more drowsy or dizzy than usual.
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Why this happens
Both amitriptyline and fexofenadine have 'anticholinergic' properties (though fexofenadine's effect is very weak). When combined, these effects can add up. Additionally, both can cause drowsiness, which may be more noticeable when they are taken at the same time.
What you should do
It is generally safe to take these together, but you should be aware of increased side effects. If you feel very sleepy or dizzy, do not drive or operate machinery. If you find the dry mouth or constipation bothersome, speak to your pharmacist or doctor. Taking fexofenadine in the morning and amitriptyline at night may help reduce daytime drowsiness.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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