Can I take Amitriptyline and Ibuprofen gel 10% together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no significant interaction between amitriptyline and ibuprofen gel. Because the ibuprofen is applied to the skin as a gel, very little of it reaches your bloodstream compared to taking a tablet. This makes it much safer to use alongside other medicines.
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Why this happens
Amitriptyline is an antidepressant that works on the brain and nerves, while ibuprofen is an anti-inflammatory. When ibuprofen is used as a 10% gel, it works locally on the area where it is applied. Only a tiny amount is absorbed into the rest of the body, which is not enough to interfere with how amitriptyline works or how it is processed by the liver.
What you should do
It is safe to use these two treatments together. Follow the instructions on the gel packaging and do not apply it to broken or damaged skin. If you develop a skin rash where you apply the gel, stop using it and speak to your pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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