Can I take Amitriptyline and Ibuprofen gel 10% together?

Why this happens

Amitriptyline is an antidepressant that works on the brain and nerves, while ibuprofen is an anti-inflammatory. When ibuprofen is used as a 10% gel, it works locally on the area where it is applied. Only a tiny amount is absorbed into the rest of the body, which is not enough to interfere with how amitriptyline works or how it is processed by the liver.

What you should do

It is safe to use these two treatments together. Follow the instructions on the gel packaging and do not apply it to broken or damaged skin. If you develop a skin rash where you apply the gel, stop using it and speak to your pharmacist.

Important precautions

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Heart conditions

Do not take amitriptyline if you have recently had a heart attack or have serious heart rhythm problems (such as heart block), as it can affect the electrical signals in your heart.

Asthma

Do not use this gel if you have asthma that is triggered or worsened by aspirin or other anti-inflammatory medicines (NSAIDs), as it can cause a severe breathing reaction even when applied to the skin.

Sun exposure

Avoid exposing the treated area of skin to direct sunlight or sunlamps during treatment and for two weeks after stopping, as the gel can make your skin significantly more sensitive to light, leading to severe rashes or burns.

Food and drink warnings

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.