Can I take Pregabalin and Prozac together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking pregabalin and Prozac (fluoxetine) together can increase the risk of side effects that affect your brain and nervous system. You may feel more drowsy, dizzy, or confused. It can also make it harder to concentrate or perform tasks that require alertness. In some cases, especially in older adults, it may lead to impaired thinking or coordination.
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Why this happens
Both medications have 'depressant' effects on the central nervous system. When taken together, these effects are additive, meaning they stack on top of each other to produce a stronger sedative effect than either drug would alone.
What you should do
You should use caution when combining these medications. Avoid driving or operating heavy machinery until you know how the combination affects you. Limit or avoid alcohol, as it will make these side effects much worse. If you feel excessively sleepy or confused, contact your doctor to discuss your dosages.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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