Can I take Atorvastatin and Mirabegron together?

Why this happens

Mirabegron can slightly interfere with a protein (CYP3A4) and a transporter (P-gp) that the body uses to break down and remove atorvastatin. This means the atorvastatin stays in your system a bit longer than usual.

What you should do

You can usually take these together, but you should be aware of any new or unusual muscle pain, tenderness, or weakness. If you notice these symptoms, or if you experience dark-coloured urine, contact your doctor. Your doctor may want to monitor you more closely when you first start taking them together or if your dose is increased.

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Severe high blood pressure

Do not take mirabegron if you have very high, uncontrolled blood pressure (180/110 mmHg or higher), as it can further increase your blood pressure.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.