Can I take Cannabis and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
Répond aux besoins du patient lignes directrices éditoriales
- TéléchargerTélécharger
- Partager
- Langue
- Discussion
Combining cannabis with sertraline can increase the risk of side effects such as extreme drowsiness, dizziness, and confusion. In rare cases, it may lead to a serious condition called serotonin syndrome, which causes symptoms like a racing heart, sweating, tremors, and agitation. Additionally, cannabis can sometimes worsen the anxiety or depression that sertraline is being used to treat.
Dans cet article :
Poursuivre la lecture ci-dessous
Why this happens
Both substances affect brain chemicals. Sertraline increases serotonin levels, and cannabis may further influence this, potentially leading to an overload (serotonin syndrome). Furthermore, cannabis can slow down the liver enzymes (specifically CYP2C19) that break down sertraline, causing the medication to build up to higher-than-intended levels in your bloodstream.
What you should do
It is best to avoid using cannabis while taking sertraline. If you do choose to use it, do so with extreme caution, start with a very low amount, and ensure someone is with you. Seek medical help immediately if you experience a rapid heartbeat, severe shivering, or confusion. Discuss your use with your GP or pharmacist, as they may need to monitor your sertraline dose more closely.
Poursuivre la lecture ci-dessous
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Traitement et médicaments
Can I take Esomeprazole and Vitamin c together?
Esomeprazole may slightly reduce how much Vitamin C your body absorbs, but this is generally not a cause for concern for most people.
Traitement et médicaments
Can I take Esomeprazole and Trazodone together?
Esomeprazole may reduce the amount of trazodone that your body absorbs. This could potentially make trazodone less effective at treating your symptoms (such as depression or sleep issues). Additionally, both medications can rarely affect the electrical activity of your heart, though this risk is generally low.
Poursuivre la lecture ci-dessous
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets liés à la santé.
Vous ne vous sentez pas bien ?
Évaluez gratuitement vos symptômes en ligne
Inscrivez-vous à la newsletter destinée aux patients
Votre dose hebdomadaire de conseils santé clairs et fiables, rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.