Can I take Levothyroxine and Prednisolone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking prednisolone may change how much levothyroxine your body needs. You might find that your thyroid levels fluctuate, potentially leading to symptoms of an overactive or underactive thyroid while you are on the steroid treatment.
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Why this happens
Prednisolone (a corticosteroid) can affect how your body processes thyroid hormones. It can slightly reduce the conversion of the inactive hormone (T4) into the active form (T3) and may also affect the levels of proteins in your blood that carry the thyroid hormone around. Additionally, if you are taking levothyroxine for an underactive thyroid, the underlying condition itself can change how quickly your body clears prednisolone from your system.
What you should do
You should inform your doctor that you are taking both medications. They may want to perform a blood test to check your thyroid levels (TSH) shortly after you start or stop taking prednisolone. Do not change your dose of either medication without consulting your healthcare provider. If you feel unusually tired, cold, or notice a racing heart and tremors, let your doctor know.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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