Puis-je prendre Levothyroxine et Simvastatine ensemble ?

Pourquoi cela se produit

Thyroid hormones influence how the body processes cholesterol and how it metabolises statin medications. An underactive thyroid can lead to higher levels of fats in the blood and may slow down the breakdown of simvastatin in the body.

You can take these medicines together, but ensure your doctor monitors your thyroid stimulating hormone (TSH) levels regularly. If your levothyroxine dose is changed, your doctor may also want to check your cholesterol levels or monitor you for any new muscle aches or pains.

Heart conditions (e.g. angina, heart failure)

If you have a heart condition, your dose must be started very low and increased slowly. Contact your doctor immediately if you experience chest pain or palpitations, as levothyroxine increases the workload on your heart.

Grossesse

You must not take simvastatin if you are pregnant or planning to become pregnant, as it may harm the developing baby. Use effective contraception while taking this medicine.

Muscle disorders (Myopathy/Rhabdomyolysis) - simvastatin

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. This is especially important if you also feel unwell or have a fever, as it can lead to serious kidney damage.

Pamplemousse et Jus de Pamplemousse

Vous devez éviter de manger du pamplemousse ou de boire du jus de pamplemousse pendant que vous prenez de la simvastatine. Le pamplemousse contient des composés qui augmentent le niveau de simvastatine dans votre sang, ce qui augmente considérablement votre risque d'effets secondaires graves, tels que des lésions musculaires (rhabdomyolyse).

Interaction with supplements (Calcium/Iron)

Do not take calcium tablets, iron supplements, or multivitamins at the same time as levothyroxine. You must leave a gap of at least 4 hours between these supplements and your levothyroxine to ensure the medicine works.

Diabète

Levothyroxine can raise blood sugar levels. If you have diabetes, you must monitor your blood glucose more closely when starting or changing your dose, as your diabetes medication may need to be increased.

Alcool

It is best to avoid or strictly limit alcohol while taking levothyroxine. While there is no direct chemical reaction, alcohol can affect thyroid function and may worsen symptoms like tiredness or mood changes.

It is best to avoid or strictly limit alcohol when taking simvastatin. Both alcohol and simvastatin can affect your liver; combining them increases the risk of liver damage and may also increase the risk of muscle side effects.

Timing of dose and food/drink

Take your levothyroxine on an empty stomach, at least 30 to 60 minutes before breakfast or any caffeine. Food, milk, and coffee prevent the medicine from being absorbed properly.

Caféine (Café/Thé)

Caffeine can significantly reduce the amount of levothyroxine your body absorbs. You should wait at least 30 to 60 minutes after taking your tablet before drinking coffee or tea.

Dairy products (Milk, Yoghurt, Cheese)

Avoid consuming dairy products at the same time as your levothyroxine. Calcium found in dairy can interfere with how your body absorbs the medicine, making it less effective. It is best to wait at least 4 hours between taking levothyroxine and consuming dairy.

Soya products

Soya can interfere with the absorption of levothyroxine. If you regularly eat or drink soya products, your doctor may need to monitor your thyroid levels more closely. Avoid consuming soya at the same time as your dose.

Kelp and Seaweed

These foods are naturally high in iodine. Too much iodine can interfere with your thyroid treatment and make your condition worse.

High-fibre foods

A diet very high in fibre can reduce the absorption of levothyroxine. If you significantly change your fibre intake, inform your doctor as your dose may need adjusting.

Taking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.