Can I take Naproxen bp and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking naproxen and pregabalin together can increase the risk of side effects such as drowsiness, dizziness, and difficulty concentrating. In some people, it may also lead to increased swelling (fluid retention) in the legs or arms.
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Why this happens
Both medications can affect the central nervous system, leading to an 'additive' effect on sleepiness. Additionally, both drugs can independently cause the body to hold onto extra fluid, which may increase the risk of swelling (oedema).
What you should do
It is generally safe to take these together if prescribed by your doctor, but you should be cautious. Avoid driving or operating machinery until you know how the combination affects you. If you notice significant swelling in your ankles or hands, or if you feel unusually dizzy, contact your GP.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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