Puis-je prendre la Sertraline et la Fluoxétine ensemble ?

Pourquoi cela se produit

Both drugs are Selective Serotonin Reuptake Inhibitors (SSRIs) that have an additive effect on serotonin levels (pharmacodynamic interaction). Furthermore, fluoxetine interferes with the liver enzymes (specifically CYP2D6 and potentially others) responsible for clearing sertraline from your body, making sertraline levels rise higher than intended (pharmacokinetic interaction).

You should not take these two medicines together unless specifically instructed and closely monitored by a specialist. If you are currently taking both, do not stop taking them abruptly, but contact your doctor immediately to discuss a safe plan. Seek urgent medical help if you experience agitation, hallucinations, a very fast heartbeat, or muscle twitching.

Dépressions et troubles anxieux

These medicines can increase thoughts of self-harm or suicide, particularly in the first few weeks of treatment or when the dose is changed. Patients under 25 are at higher risk. Seek medical help immediately if your mood worsens or you have distressing thoughts.

Syndrome sérotoninergique

Taking these medicines with other drugs that affect serotonin (such as St John’s Wort, tramadol, or triptans for migraine) can cause a life-threatening condition called serotonin syndrome. Symptoms include high fever, agitation, confusion, trembling, and sweating.

Troubles de la coagulation

These medicines can increase your risk of bleeding, especially in the stomach. This risk is much higher if you also take aspirin, ibuprofen (NSAIDs), or blood-thinning medicines like warfarin. Seek medical advice for unusual bruising or black, tarry stools.

Faible taux de sodium dans le sang (Hyponatrémie)

These medicines can cause the level of sodium in your blood to fall too low, which can be serious. This is more common in elderly patients. Symptoms include extreme tiredness, confusion, muscle twitching, or fits.

Alcool

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with antidepressants can increase drowsiness, dizziness, and coordination problems, and may make your depression or anxiety worse. There is also an increased risk of liver damage when mixing alcohol with certain medications.

Jus de pamplemousse

Vous devriez éviter de boire de grandes quantités de jus de pamplemousse pendant que vous prenez de la sertraline. Le pamplemousse peut augmenter le niveau de sertraline dans votre sang, ce qui peut augmenter le risque d'effets secondaires.

Caféine (Café, thé, boissons énergisantes)

Limit your intake of caffeine. These medicines can sometimes cause jitteriness, anxiety, or difficulty sleeping. Caffeine can make these side effects worse.

Vous prenez plusieurs médicaments ? Notre Vérificateur d'Interactions Médicamenteuses vous aide à vérifier si vos ordonnances, médicaments en vente libre et suppléments peuvent être pris ensemble en toute sécurité. Recherchez simplement vos médicaments pour voir les interactions potentielles et savoir quoi faire à leur sujet.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.