Can I take Amitriptyline and Zopiclone together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking amitriptyline and zopiclone together can make you feel extremely drowsy, dizzy, and confused. It significantly increases the risk of falling over, especially in the dark or when getting out of bed at night. It can also cause your breathing to become very slow or shallow, and may lead to severe coordination problems.
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Why this happens
Both medicines work by slowing down the activity in your central nervous system (your brain and nerves). Amitriptyline is a tricyclic antidepressant with sedative properties, and zopiclone is a 'Z-drug' used for sleep. When used together, their sedative effects add up (an additive effect), making the overall impact much stronger than taking either medicine alone.
What you should do
You should only take these two medicines together if your doctor is specifically aware you are using both and has told you to do so. If you are prescribed both, take them exactly as directed, usually right before bed. Do not drive, operate machinery, or drink any alcohol while using this combination. If you feel excessively sleepy the next day or have trouble breathing, contact your doctor immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
24 janvier 2026 | Publié à l'origine
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