Can I take Aspirin and Methotrexate together?
Drug interaction guide
Originally published 24 Jan 2026
Répond aux besoins du patient lignes directrices éditoriales
- TéléchargerTélécharger
- Partager
- Langue
- Discussion
Taking aspirin with methotrexate can significantly increase the levels of methotrexate in your blood. This can lead to serious side effects, including damage to your bone marrow (which helps fight infection), kidney problems, and severe stomach or mouth ulcers.
Dans cet article :
Poursuivre la lecture ci-dessous
Why this happens
Aspirin interferes with how your kidneys remove methotrexate from your body. It also 'bumps' methotrexate off the proteins in your blood that normally keep it inactive, leaving more of the active drug to cause potential harm.
What you should do
Do not take aspirin (including low-dose 'baby' aspirin) while taking methotrexate unless your specialist doctor has specifically told you to do so. If you need pain relief, paracetamol is usually a safer choice. If you are already taking both, contact your doctor immediately if you notice unusual bruising, bleeding, a sore throat, or mouth ulcers.
Poursuivre la lecture ci-dessous
Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Traitement et médicaments
Can I take Atorvastatin and Ramipril together?
There is no significant harmful interaction between atorvastatin and ramipril. In fact, these two medicines are very commonly prescribed together to help protect the heart and blood vessels.
Traitement et médicaments
Can I take Magnesium and Warfarin together?
Taking magnesium supplements at the same time as warfarin may slightly reduce how well warfarin works. This could potentially make your blood more likely to clot than intended.
Poursuivre la lecture ci-dessous
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
24 janvier 2026 | Publié à l'origine
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets liés à la santé.
Vous ne vous sentez pas bien ?
Évaluez gratuitement vos symptômes en ligne
Inscrivez-vous à la newsletter destinée aux patients
Votre dose hebdomadaire de conseils santé clairs et fiables, rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.