Can I take Atorvastatin and Lions mane together?
Drug interaction guide
Originally published 24 Jan 2026
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There is no evidence of a direct interaction between atorvastatin and Lion's Mane mushroom. However, both substances can affect the liver and blood sugar levels, which may lead to additive effects in some people.
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Why this happens
Atorvastatin is processed by the liver (specifically the CYP3A4 enzyme). While Lion's Mane is not known to strongly block this enzyme, it contains compounds that can lower blood sugar and potentially influence liver function. If taken together, they might theoretically increase the risk of side effects like muscle aches or low blood sugar, though this has not been proven in clinical studies.
What you should do
It is generally considered safe to take these together, but you should inform your doctor or pharmacist before starting any new supplement. Monitor yourself for any unusual muscle pain, weakness, or tiredness, which are known side effects of statins. If you have diabetes, monitor your blood sugar levels more closely when starting Lion's Mane.
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Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
24 janvier 2026 | Publié à l'origine
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