Can I take Warfarin and Methotrexate together?
Drug interaction guide
Originally published 24 Jan 2026
Répond aux besoins du patient lignes directrices éditoriales
- TéléchargerTélécharger
- Partager
- Langue
- Discussion
Taking methotrexate while on warfarin can significantly increase your risk of bleeding. This might show up as unusual bruising, nosebleeds, bleeding gums, or in more serious cases, internal bleeding. It can also cause your blood-clotting tests (INR) to become unstable.
Dans cet article :
Poursuivre la lecture ci-dessous
Why this happens
Methotrexate can displace warfarin from the proteins in your blood that normally carry it, leaving more 'active' warfarin to thin your blood. Additionally, methotrexate can sometimes affect how the liver processes warfarin and may cause damage to the lining of the stomach or gut, which increases the risk of a bleed starting.
What you should do
You must speak to your doctor before taking these together. If you are prescribed both, you will need much more frequent blood tests (INR) to monitor how quickly your blood clots. Seek urgent medical help if you notice any signs of bleeding, such as blood in your urine, black tarry stools, or coughing up blood.
Poursuivre la lecture ci-dessous
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Traitement et médicaments
Can I take Azithromycin and Terbutaline together?
Taking azithromycin and terbutaline together may increase the risk of developing an irregular heart rhythm. While this is rare, it can be serious. Symptoms to watch out for include heart palpitations (a fluttering feeling in the chest), dizziness, fainting, or sudden shortness of breath.
Traitement et médicaments
Can I take Amlopadine and Atorvastatin together?
Taking amlodipine and atorvastatin together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, tenderness, or weakness (a condition called myopathy). In rare cases, this can lead to a more serious muscle breakdown called rhabdomyolysis.
Poursuivre la lecture ci-dessous
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
24 janvier 2026 | Publié à l'origine
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets liés à la santé.
Vous ne vous sentez pas bien ?
Évaluez gratuitement vos symptômes en ligne
Inscrivez-vous à la newsletter destinée aux patients
Votre dose hebdomadaire de conseils santé clairs et fiables, rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.