amelogenin X-linked
Dernière mise à jour 3 déc. 2025
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
The AMELX gene provides instructions for making a protein called amelogenin, which is essential for normal tooth development. Amelogenin is involved in the formation of tooth enamel, which is the hard, white material that forms the protective outer layer of each tooth. Enamel is composed mainly of mineral crystals. These microscopic crystals are organized in a way to give enamel strength and durability. Amelogenin acts as a scaffold to separate and support the crystals as they grow. Amelogenin is removed from the developing crystals when it is no longer needed, leaving mature enamel that contains very little protein.
Normal function
The AMELX gene provides instructions for making a protein called amelogenin, which is essential for normal tooth development. Amelogenin is involved in the formation of tooth enamel, which is the hard, white material that forms the protective outer layer of each tooth. Enamel is composed mainly of mineral crystals. These microscopic crystals are organized in a way to give enamel strength and durability. Amelogenin acts as a scaffold to separate and support the crystals as they grow. Amelogenin is removed from the developing crystals when it is no longer needed, leaving mature enamel that contains very little protein.
The AMELX gene is located on the X chromosome. Males have a single copy of the X chromosome, and thus a single copy of the AMELX gene, in each cell. Females have two copies of the X chromosome, and thus two copies of the AMELX gene, in each cell. However, in females, the X chromosome undergoes a process called X-inactivation. Early in female embryonic development, one of the two X chromosomes is randomly and permanently inactivated in cells other than egg cells. X-inactivation ensures that females, like males, have only one active copy of the X chromosome in each body cell. Because of this, females also only have one active copy of the AMELX gene in each body cell.
Conditions referring to this gene or chromosome
Other names
AIH1
ALGN
AMELX_HUMAN
AMG
AMGL
AMGX
Related patient information and medicines
Patient information leaflet
Maladies de stockage du glycogène
Who ge... Glycogen storage disorders are rare. It is estimated that about one baby in every 20,000 to 40,000 babies born has a glycogen storage disorder. If both parents are carriers of the faulty gene, the chance of each one of their children being affected by the glycogen storage disorder is 1 in 4. Mode de transmission lié à l'X Ceci occurs in.
Patient information leaflet
Hémophilie
Haemophilia is a rare bleeding disorder that affects your ability to make a clot. Both haemophilias are inherited as X-linked recessive conditions. X-linked inheritance pattern Haemophilia is inherited in a pattern called 'X-linked recessive inheritance'. The haemophilia gene is 'carried' by women but does not usually cause problems in girls or.
Patient information leaflet
Dystrophie musculaire de Duchenne
Each person inherits a set of genes from their father and another set from their mother. The genes have been copied from the parents' cells into the child's cells. Boys have one X chromosome and one Y chromosome; girls have two X chromosomes. DMD is inherited in a pattern called 'X-linked inheritance'. The DMD gene is 'carried' by women but does.
Patient information leaflet
Puis-je prendre des suppléments de fer et du prégabaline ensemble ?
Il y a no known direct interaction between iron supplements and pregabalin. Taking these two medications together is generally considered safe and they do not interfere with how each other works in the body. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take.
Patient information leaflet
Contraceptifs réversibles à longue durée d'action
Contraceptifs réversibles à longue durée d'action are very effective birth control methods. When you use one of these, you do not have to rely on remembering something every day. Wha... There are four types de long-acting reversible contraception (LARC). The contraceptive implant. Different people will prefer different options. Pros and cons of each are.
Patient information leaflet
Accès simple et sécurisé à votre dossier médical NHS
Patient.info s'est associé à ORB Connect - a UK, clinician-led, secure platform - to help you see and download your NHS GP records clearly and in one place. Your health information is one of your most important resources. Why we’ve partnered with ORB We’ve teamed up with ORB - a secure, clinician-led UK service - to make reading and downloading.
Lectures complémentaires et références
- amelogenin X-linked; MedlinePlus, National Library of Medicine.
- Hu JC, Chan HC, Simmer SG, Seymen F, Richardson AS, Hu Y, Milkovich RN, Estrella NM, Yildirim M, Bayram M, Chen CF, Simmer JP. Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6. PLoS One. 2012;7(12):e52052. doi: 10.1371/journal.pone.0052052. Epub 2012 Dec 14.
- Margolis HC, Beniash E, Fowler CE. Role of macromolecular assembly of enamel matrix proteins in enamel formation. J Dent Res. 2006 Sep;85(9):775-93. doi: 10.1177/154405910608500902.
- Sharmin N, Yuan J, Chow AK. Using computer-generated protein models to analyze mutations linked to Amelogenesis Imperfecta. PLoS One. 2025 Jun 26;20(6):e0326679. doi: 10.1371/journal.pone.0326679. eCollection 2025.
- Smith CEL, Poulter JA, Antanaviciute A, Kirkham J, Brookes SJ, Inglehearn CF, Mighell AJ. Amelogenesis Imperfecta; Genes, Proteins, and Pathways. Front Physiol. 2017 Jun 26;8:435. doi: 10.3389/fphys.2017.00435. eCollection 2017.
- Wang SK, Zhang H, Lin HC, Wang YL, Lin SC, Seymen F, Koruyucu M, Simmer JP, Hu JC. AMELX Mutations and Genotype-Phenotype Correlation in X-Linked Amelogenesis Imperfecta. Int J Mol Sci. 2024 Jun 1;25(11):6132. doi: 10.3390/ijms25116132.
- Wright JT, Li Y, Suggs C, Kuehl MA, Kulkarni AB, Gibson CW. The role of amelogenin during enamel-crystallite growth and organization in vivo. Eur J Oral Sci. 2011 Dec;119 Suppl 1(Suppl 1):65-9. doi: 10.1111/j.1600-0722.2011.00883.x.
- Wright JT, Torain M, Long K, Seow K, Crawford P, Aldred MJ, Hart PS, Hart TC. Amelogenesis imperfecta: genotype-phenotype studies in 71 families. Cells Tissues Organs. 2011;194(2-4):279-83. doi: 10.1159/000324339. Epub 2011 May 19.
- Wright JT. The molecular etiologies and associated phenotypes of amelogenesis imperfecta. Am J Med Genet A. 2006 Dec 1;140(23):2547-55. doi: 10.1002/ajmg.a.31358.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.