parkin RBR E3 ubiquitin protein ligase
Dernière mise à jour 17 Jul 2023
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La PRKN gene, one of the largest human genes, provides instructions for making a protein called parkin. Parkin plays a role in the cell machinery that breaks down (degrades) unneeded proteins by tagging damaged and excess proteins with molecules called ubiquitin. Ubiquitin serves as a signal to move unneeded proteins into specialized cell structures known as proteasomes, where the proteins are degraded. The ubiquitin-proteasome system acts as the cell's quality control system by disposing of damaged, misshapen, and excess proteins. This system also regulates the availability of proteins that are involved in several critical cell activities, such as the timing of cell division and growth. Because of its activity in the ubiquitin-proteasome system, parkin belongs to a group of proteins called E3 ubiquitin ligases.
Normal function
La PRKN gene, one of the largest human genes, provides instructions for making a protein called parkin. Parkin plays a role in the cell machinery that breaks down (degrades) unneeded proteins by tagging damaged and excess proteins with molecules called ubiquitin. Ubiquitin serves as a signal to move unneeded proteins into specialized cell structures known as proteasomes, where the proteins are degraded. The ubiquitin-proteasome system acts as the cell's quality control system by disposing of damaged, misshapen, and excess proteins. This system also regulates the availability of proteins that are involved in several critical cell activities, such as the timing of cell division and growth. Because of its activity in the ubiquitin-proteasome system, parkin belongs to a group of proteins called E3 ubiquitin ligases.
Parkin appears to be involved in the maintenance of mitochondria, the energy-producing centers in cells. However, little is known about its role in mitochondrial function. Research suggests that parkin may help trigger the destruction of mitochondria that are not working properly.
Studies of the structure and activity of parkin have led researchers to propose several additional activities for this protein. Parkin may act as a tumour suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. Parkin may also regulate the supply and release of sacs called synaptic vesicles from nerve cells. Synaptic vesicles contain chemical messengers that transmit signals from one nerve cell to another.
Conditions referring to this gene or chromosome
Other names
AR-JP
PARK2
parkin
Parkinson disease (autosomal recessive, juvenile) 2, parkin
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
PDJ
PRKN2_HUMAN
ubiquitin E3 ligase
Related patient information and medicines
Patient information leaflet
Puis-je prendre du Lactulose et du Ropinirole ensemble ?
It is generally safe to take these two medicines together. Why this happens Lactulose is a laxative that stays in the bowel and is not absorbed into the bloodstream. Ropinirole is absorbed into the blood to treat Parkinson's disease or Restless Legs Syndrome. Because they work in different parts of the body and are processed through different.
Patient information leaflet
Lentilles de contact
Care of contact lenses is aimed at preventing them from becoming contaminated avec chemicals or debris, or with bugs (pathogens) that can damage your eyes. In particular a bug called acanthamoeba can cause serious eye infection. Care of your eyes involves washing your hands, thoroughly and with soap (avoiding moisturising soaps, which are not good.
Patient information leaflet
régime méditerranéen
Research has also shown th... Type 2 diabetes. High blood pressure. Obesity . Some cancers. Parkinson's disease. maladie d'Alzheimer. It can also be useful for people wishing to lose weight as it is rich in fruit and vegetables and lower in sugars and saturated fats than a typical Western diet. Switching from a Western to a Mediterranean diet.
Patient information leaflet
Puis-je prendre Amitriptyline et Esomeprazole ensemble ?
Taking esomeprazole alongside amitriptyline may increase the levels of amitriptyline in your bloodstream. This could make you ... Why this happens Amitriptyline is broken down in the liver by specific proteins (enzymes). Using other medicines Taking multiple medicines. Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions,.
Patient information leaflet
maladie de Parkinson
La main symptoms of Parkinson's disease are usually stiffness, shaking (tremor), and slowness of movement. People with Parkinson's may also develop other symptoms (listed below). What is Parkinson's disease. maladie de Parkinson is a progressive neurological degeneration of certain cells (called dopaminergic cells) within a specific part of the.
Patient information leaflet
dystrophie musculaire
dystrophie musculaire est an inherited (genetic) disorder causing. There are different types of muscular dystrophy, which vary as to how severe they are, ranging from very mild to severe. The different types also vary as to what age they begin. If muscular dystrophy is suspected, tests can help to make an accurate diagnosis. Other people in the family.
Lectures complémentaires et références
- parkin RBR E3 ubiquitin protein ligase; MedlinePlus, National Library of Medicine.
- Abou-Sleiman PM, Muqit MM, Wood NW. Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci. 2006 Mar;7(3):207-19. doi: 10.1038/nrn1868.
- Dawson TM, Dawson VL. The role of parkin in familial and sporadic Parkinson's disease. Mov Disord. 2010;25 Suppl 1(0 1):S32-9. doi: 10.1002/mds.22798.
- Denison SR, Callahan G, Becker NA, Phillips LA, Smith DI. Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. Genes Chromosomes Cancer. 2003 Sep;38(1):40-52. doi: 10.1002/gcc.10236.
- Denison SR, Wang F, Becker NA, Schule B, Kock N, Phillips LA, Klein C, Smith DI. Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene. 2003 Nov 13;22(51):8370-8. doi: 10.1038/sj.onc.1207072.
- Kay DM, Stevens CF, Hamza TH, Montimurro JS, Zabetian CP, Factor SA, Samii A, Griffith A, Roberts JW, Molho ES, Higgins DS, Gancher S, Moses L, Zareparsi S, Poorkaj P, Bird T, Nutt J, Schellenberg GD, Payami H. A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2. Neurology. 2010 Sep 28;75(13):1189-94. doi: 10.1212/WNL.0b013e3181f4d832.
- Mira MT, Alcais A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Dore C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E. Susceptibility to leprosy is associated with PARK2 and PACRG. Nature. 2004 Feb 12;427(6975):636-40. doi: 10.1038/nature02326. Epub 2004 Jan 25.
- Narendra DP, Youle RJ. Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal. 2011 May 15;14(10):1929-38. doi: 10.1089/ars.2010.3799. Epub 2011 Mar 3.
- Picchio MC, Martin ES, Cesari R, Calin GA, Yendamuri S, Kuroki T, Pentimalli F, Sarti M, Yoder K, Kaiser LR, Fishel R, Croce CM. Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer. Clin Cancer Res. 2004 Apr 15;10(8):2720-4. doi: 10.1158/1078-0432.ccr-03-0086.
- Pramstaller PP, Schlossmacher MG, Jacques TS, Scaravilli F, Eskelson C, Pepivani I, Hedrich K, Adel S, Gonzales-McNeal M, Hilker R, Kramer PL, Klein C. Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers. Ann Neurol. 2005 Sep;58(3):411-22. doi: 10.1002/ana.20587.
- Schurr E, Alcais A, de Leseleuc L, Abel L. Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium leprae. Semin Immunol. 2006 Dec;18(6):404-10. doi: 10.1016/j.smim.2006.07.005. Epub 2006 Sep 14.
- Shimura H, Hattori N, Kubo Si, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet. 2000 Jul;25(3):302-5. doi: 10.1038/77060.
- Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA. Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet. 2010 Jan;42(1):77-82. doi: 10.1038/ng.491. Epub 2009 Nov 29.
- von Coelln R, Dawson VL, Dawson TM. Parkin-associated Parkinson's disease. Cell Tissue Res. 2004 Oct;318(1):175-84. doi: 10.1007/s00441-004-0924-4. Epub 2004 Jul 30.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.