troponin I2, fast skeletal type
Dernière mise à jour 18 Aug 2020
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La TNNI2 gene provides instructions for making one form of a protein called troponin I. The troponin I protein produced from the TNNI2 gene is found in skeletal muscles, which are the muscles used for movement. Troponin I is one of three proteins that make up the troponin complex in muscle cells. The troponin complex, along with calcium, helps regulate muscle tensing (contraction).
Normal function
La TNNI2 gene provides instructions for making one form of a protein called troponin I. The troponin I protein produced from the TNNI2 gene is found in skeletal muscles, which are the muscles used for movement. Troponin I is one of three proteins that make up the troponin complex in muscle cells. The troponin complex, along with calcium, helps regulate muscle tensing (contraction).
The troponin complex is part of a structure called the sarcomere, which is the basic unit of muscle contraction. Sarcomeres contain thick and thin filaments. The overlapping thick and thin filaments attach (bind) to each other and release, which allows the filaments to move relative to one another so that muscles can contract.
When calcium levels are low, the troponin complex blocks the binding between the thick and thin filaments that is needed for muscle contraction. An increase in calcium levels causes structural changes in the troponin complex, which exposes the binding sites and allows the thick and thin filaments to interact, leading to muscle contraction.
Conditions referring to this gene or chromosome
Other names
AMCD2B
DA2B
FSSV
fsTnI
troponin I fast twitch 2
troponin I type 2 (skeletal, fast)
troponin I, fast skeletal muscle
troponin I, fast skeletal muscle isoform 1
troponin I, fast skeletal muscle isoform 2
troponin I, fast-twitch isoform
troponin I, fast-twitch skeletal muscle isoform
troponin I, skeletal, fast
Related patient information and medicines
Patient information leaflet
Enzymes cardiaques
The cardiac enzyme levels that are tested are called cardiac troponins. Normal (skeletal) muscle aussi produces troponins mais troponins T and I are more specific for heart muscle and so are the cardiac enzymes that are usually tested. Before troponins, different blood tests were checked looking for heart muscle damage. Is troponin a... Troponin is.
Patient information leaflet
Crise cardiaque
It is very important to get medical help very urgently, to reduce the chances of permanent damage to the heart muscle. What should I do if I think I am having a heart attack. Dial 999/112/911 for an ambulance immediately. Then, if you have some, take 300 mg of aspirin (see below for the reas... Blood tests. A blood test that measures a chemical.
Patient information leaflet
Douleur thoracique
Based on what they find, he or she may advise you... Investigations for chest pain can include: An ECG (electrocardiogram or 'heart tracing') There are often typical changes to the normal pattern of the 'heart tracing' (electrocardiogram, or ECG) in a heart attack. Blood tests A blood test that measures a chemical called troponin is the usual test.
Patient information leaflet
Puis-je prendre de la biotine et du collagène ensemble ?
If you are due to have a blood test, tell your doctor or the lab staff that you are taking a biotin supplement. Important precautions Blood test interference Biotin can significantly interfere with laboratory blood tests, including thyroïde function and heart attack markers (troponin), leading to dangerously incorrect results. You must stop taking.
Patient information leaflet
Puis-je prendre de la biotine et de la vitamine D ensemble ?
However, ... If you are having blood work done, inform your doctor or the lab technician that you are taking a biotin supplement. Important precautions Blood tests Biotin can significantly interfere with laboratory blood tests, including thyroid function and heart attack markers (troponin), leading to dangerously incorrect results. You must stop.
Patient information leaflet
Insuffisance respiratoire
They may help to work out the cause and also to detect any factors that may be worsening the respiratory failure, such as a low blood haemoglobin level (anaemia). Troponin blood tests : these are used to determine if there has been recent heart injury - for example, a heart attack which may have caused the respiratory failure. Thyroid function.
Lectures complémentaires et références
- troponin I2, fast skeletal type; MedlinePlus, National Library of Medicine.
- Beck AE, McMillin MJ, Gildersleeve HI, Kezele PR, Shively KM, Carey JC, Regnier M, Bamshad MJ. Spectrum of mutations that cause distal arthrogryposis types 1 and 2B. Am J Med Genet A. 2013 Mar;161A(3):550-5. doi: 10.1002/ajmg.a.35809. Epub 2013 Feb 7.
- Drera B, Zoppi N, Barlati S, Colombi M. Recurrence of the p.R156X TNNI2 mutation in distal arthrogryposis type 2B. Clin Genet. 2006 Dec;70(6):532-4. doi: 10.1111/j.1399-0004.2006.00713.x. No abstract available.
- Ochala J. Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction. J Mol Med (Berl). 2008 Nov;86(11):1197-204. doi: 10.1007/s00109-008-0380-9. Epub 2008 Jun 24.
- Toydemir RM, Bamshad MJ. Sheldon-Hall syndrome. Orphanet J Rare Dis. 2009 Mar 23;4:11. doi: 10.1186/1750-1172-4-11.
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