Can I take Amitriptyline and Paracetamol together?

It is generally considered safe to take amitriptyline and paracetamol together.

Amitriptyline and paracetamol are processed by the body using different pathways and do not interfere with how the other drug works, is absorbed, or is cleared from the system.

How to take amitriptyline and paracetamol

• You can take these medicines together as prescribed or according to the packet instructions.

• Always ensure you do not exceed the maximum daily dose of paracetamol (usually 4 grams or eight 500mg tablets in 24 hours).

• If you feel unusually drowsy, speak to your doctor or pharmacist.

Important precautions

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Liver disease or heavy alcohol consumption

Taking paracetamol if you have liver problems or drink large amounts of alcohol significantly increases the risk of severe, life-threatening liver damage, even at standard doses.

Heart conditions (e.g. recent heart attack, heart rhythm disorders)

Amitriptyline can affect your heart rhythm and should not be used if you have recently had a heart attack or have certain heart rhythm problems, as it may lead to dangerous cardiac events.

Glaucoma (specifically acute angle-closure glaucoma)

Amitriptyline can increase the pressure inside your eye. If you have glaucoma, it can trigger an acute attack, which is a medical emergency.

Food and drink warnings

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Caffeine (coffee, tea, energy drinks)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen these side effects or increase feelings of anxiety and restlessness.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.