Amitriptyline
Elavil
Revu par Dr Colin Tidy, MRCGPDernière mise à jour par Michael Stewart, MRPharmSLast updated 5 Oct 2023
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Gardez vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.
Amitriptyline may make you feel sleepy. If this happens, do not drive and do not use tools or machines. Do not drink alcohol.
Common side effects of amitriptyline include dry mouth, constipation, dizziness, sleepiness, and blurred vision.
Tell your doctor if you experience any troublesome side effects.
Dans cet article:
Video picks for Médicaments du système nerveux
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About amitriptyline
Type de médicament | Un antidépresseur tricyclique |
Utilisé pour | Depression, nerve pain, headaches and migraine, bedwetting in children (nocturnal enuresis) |
Aussi appelé (États-Unis) | Elavil® |
Disponible sous forme de | Comprimés et médicaments liquides oraux |
What is amitriptyline used for?
Retour au sommaireAmitriptyline belongs to a group of medicines known as antidépresseurs tricycliques. It is commonly used to help ease certain types of la douleur nerveuse, and also to help prevent les migraines. It can also be used to help children with bedwetting problems.
It has been traditionally prescribed for the treatment of depression, although it is rarely used for this nowadays.
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Side effects of amitriptyline
Retour au sommaireThe most common side effects of amitriptyline are:
Bouche sèche.
Constipation.
Diarrhée.
Sensation de nausée.
Feeling dizzy or lightheaded - especially when standing up.
Feeling sleepy.
Vision floue.
Douleurs d'estomac.
Vous trouverez une liste complète dans la notice d'information du fabricant fournie avec votre médicament. Les effets indésirables s'améliorent souvent à mesure que votre corps s'adapte au nouveau médicament, mais parlez-en à votre médecin ou pharmacien si l'un des effets suivants persiste ou devient gênant.
How to manage amitriptyline side effects
Retour au sommaireCommon amitriptyline side effects | Que puis-je faire si je ressens cela ? |
Bouche sèche | Essayez de mâcher du chewing-gum sans sucre ou de sucer des bonbons sans sucre |
Constipation | Essayez de manger un régime bien équilibré contenant beaucoup de fibres et buvez beaucoup d'eau chaque jour |
Feeling sleepy, blurred vision | Do not drive and do not use tools or machines until you feel better. Do not drink alcohol |
Feeling dizzy or light-headed when getting up | Getting up more slowly may help. If you begin to feel faint, sit down and wait until the feeling passes |
Feeling sick, diarrhoea, stomach pain | Stick to simple meals - avoid rich or spicy foods. Drink plenty of water to replace lost fluids |
Other side effects include feeling anxious or confused, sleeping problems, problems passing urine, tingling feelings, breast tenderness, problems when having sex, changes in appetite and weight, changes in the way things taste, ringing noise in the ears, itchy skin rash, hair loss, increased sweating, changes in heart rate or rhythm | Si l'un de ces éléments devient problématique, consultez votre médecin pour obtenir des conseils |
If you experience any other symptoms which you think may be due to amitriptyline, speak with your doctor or pharmacist for further advice.
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Who should not take amitriptyline?
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking amitriptyline it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
If you have an overactive thyroid gland.
Si vous avez un problème avec le fonctionnement de votre foie.
Si vous avez de l'épilepsie.
Si vous avez un taux de sucre dans le sang élevé (diabète sucré).
Si vous avez eu des problèmes de constipation.
Si vous avez des difficultés à uriner, ou si vous avez eu des problèmes de prostate.
If you have a heart disorder or blood vessel disease.
Si vous avez déjà eu un problème de santé mentale (en particulier, un trouble bipolaire ou une psychose).
If you have increased pressure in your eyes, a condition called glaucoma.
If you have been told you have a tumour on your adrenal gland, called phaeochromocytoma.
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal and complementary medicines. This is especially important if you have recently taken a medicine for depression, known as a monoamine-oxidase inhibitor (MAOI).
Si vous avez déjà eu une réaction allergique à un médicament.
How to take amitriptyline
Retour au sommaireRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about amitriptyline and will provide you with a full list of the side effects which you may experience from taking it.
Take amitriptyline exactly as your doctor tells you to. It is usually prescribed as a single dose to be taken at bedtime, although your dose may differ from this.
The directions for taking it will be printed on the label of the pack to remind you what the doctor has said to you. If you have any questions about what dose to take, ask your pharmacist for advice.
Your doctor is likely to prescribe you a small dose when you first start taking it, and then increase your dose gradually as your body gets used to it.
Many people find if helps to swallow the tablets with a drink of water. You can take amitriptyline before or after food.
If you forget to take a dose, take one as soon as you remember. If when you remember, it is nearly time for your next dose then take your next dose when it is due but leave out the missed dose. Do not take two doses at the same time to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireEssayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.
If you are taking amitriptyline for depression, you may feel that it is not working for you straightaway. It can take a week or two for the effect to build up, and 4-6 weeks before you feel the full benefit. It is important that you do not stop taking it thinking it is not helping.
While you feel depressed, you may have distressing thoughts, and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway.
There are several types of antidepressants - each type works in a slightly different way and can have different side effects. If you find that amitriptyline does not suit you, then let your doctor know, as another antidepressant may be found that does.
Your doctor will recommend that you do not drink alcohol while you are on amitriptyline. This is because alcohol increases the risk that you will experience side effects.
Some people who take amitriptyline find that their skin becomes more sensitive to sunlight than usual. Try to avoid strong sunlight until you know how your skin reacts, or use a sun cream with a high sun protection factor. Do not use sunbeds.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because a number of medicines can increase the risk of side effects from amitriptyline, including some strong painkillers, flu remedies and antihistamines.
If you have diabetes you may need to check your blood glucose more frequently. This is because amitriptyline can alter the levels of sugar in your blood. Your doctor will advise you about this.
If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking amitriptyline as it can interfere with some anaesthetics.
Continue to take amitriptyline unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor may want you to reduce your dose gradually when this becomes necessary.
How to store amitriptyline
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Never take more than the prescribed dose. Tricyclic antidepressants can be dangerous in overdose. If you suspect that you or someone else might have taken an overdose, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.
Questions fréquemment posées
Retour au sommaireWhy shouldn't you take amitriptyline after 8pm?
Amitriptyline is best taken before 8pm to avoid morning grogginess. Taking it earlier helps reduce drowsy side effects the next day.
Is amitriptyline a strong sleeping pill?
Amitriptyline is not classed as a traditional sleeping pill, but at low doses it can make you feel drowsy and help with sleep problems. Doctors sometimes prescribe it off-label for insomnia, especially if pain or anxiety is also a factor.
Is amitriptyline a strong pain killer?
Amitriptyline is not a strong painkiller like opioids, but it can be very effective for certain types of long-term pain, especially nerve pain, migraines, or tension headaches.
Is amitriptyline addictive?
Amitriptyline is not addictive, but stopping suddenly may cause withdrawal symptoms. Always reduce the dose gradually under your doctor's advice.
Why does amitriptyline cause weight gain?
Amitriptyline can cause weight gain because it may increase appetite, slow down metabolism, and make you feel more tired, which can reduce activity levels. Some people also experience fluid retention. Not everyone gains weight.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Amitriptyline Tablets 10 mg, 25 mg, 50 mg; Brown and Burk UK Ltd, The electronic Medicines Compendium. Dated January 2022.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 4 Oct 2026
5 Oct 2023 | Dernière version

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