Can I take Amlodipine and Citalopram together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amlodipine and citalopram together may increase the risk of developing an abnormal heart rhythm. While both are commonly prescribed together, they can both affect the electrical activity of your heart. In rare cases, this can lead to a serious condition called QT prolongation, where the heart muscle takes longer than normal to recharge between beats. This can cause palpitations, dizziness, or fainting.
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Why this happens
Both medications have the potential to affect the 'QT interval' (the electrical timing of the heart). Citalopram is known to cause this effect, especially at higher doses, and amlodipine may occasionally contribute to this or change how the heart responds to electrical signals.
What you should do
Back to contentsFor most people, this combination is safe, but you should use caution. Ensure your doctor knows you are taking both. Seek medical help immediately if you feel a sudden fast or pounding heartbeat, severe dizziness, or if you faint. Your doctor may occasionally want to check your heart rhythm with an ECG (heart trace) or monitor your salt levels (electrolytes) through blood tests.
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Important precautions
Back to contentsHeart rhythm disorders (Long QT syndrome)
Do not take citalopram if you have a history of abnormal heart rhythms or are taking other medicines that affect heart rhythm, as it can cause a life-threatening heart rhythm change.
Severe aortic stenosis
Amlodipine can cause a dangerous drop in blood pressure if you have a severely narrowed heart valve (aortic stenosis).
Troubles de la coagulation
Citalopram increases your risk of serious bleeding, especially if you are also taking aspirin, warfarin, or other blood-thinning medicines.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the concentration of amlodipine in your blood, which may make your blood pressure drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid drinking large amounts of grapefruit juice while taking this medicine.
Alcool
Drinking alcohol while taking these medicines can make you feel more sleepy or dizzy. It is best to stop drinking alcohol or keep your intake to a minimum until you see how the medicines affect you.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine

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