Can I take Amlodopine and Tramadol together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small risk that tramadol could slightly interfere with how amlodipine is processed in your body, though the main concern is the combined effect on your blood pressure and heart rate.
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Why this happens
Both drugs can lower blood pressure through different pathways. Amlodipine relaxes your blood vessels, while tramadol can affect the central nervous system and occasionally cause 'orthostatic hypotension' (a drop in blood pressure upon standing). Additionally, both are processed by the liver, which can sometimes lead to one drug affecting the levels of the other.
What you should do
It is generally safe to take these together, but you should be cautious. When starting tramadol or increasing your dose, get up slowly from a sitting or lying position to avoid dizziness. If you feel very dizzy, faint, or notice a very slow heartbeat, contact your doctor. It is a good idea to monitor your blood pressure at home more frequently when you first start taking both.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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