Puis-je prendre Apixaban et Tramadol ensemble ?

Pourquoi cela se produit

Tramadol can inhibit the reuptake of serotonin, which platelets need to clump together and form clots. Additionally, both drugs are processed by the same liver enzymes (CYP3A4), meaning tramadol could potentially slow down the breakdown of apixaban, leading to higher levels of the blood thinner in your system.

Use this combination with caution. You should only take these together if specifically prescribed by your doctor. Watch closely for signs of bleeding, such as unusual bruising, blood in your urine or stools (which may look black and tarry), or persistent nosebleeds. If you experience a fall or a head injury while taking both, seek medical advice immediately even if you feel fine.

Active bleeding or high risk of bleeding

You must seek immediate medical attention if you have a serious fall or head injury, even if you feel fine, as apixaban increases the risk of internal bleeding which can be life-threatening.

Épilepsie ou antécédents de crises

Tramadol can increase the risk of having a fit (seizure), even at normal doses. This risk is higher if you already have epilepsy or are taking certain antidepressants.

Concomitant use of NSAIDs (e.g. ibuprofen, naproxen)

Do not take anti-inflammatory painkillers like ibuprofen while on these medicines without medical advice. Combining them with apixaban significantly increases your risk of serious stomach bleeding.

Alcool

You must avoid drinking alcohol while taking tramadol. Both substances affect the central nervous system; combining them significantly increases the risk of dangerous side effects, such as extreme drowsiness, breathing difficulties, and loss of consciousness.

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Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.