Puis-je prendre Atorvastatine et Rivaroxaban ensemble ?

Pourquoi cela se produit

Both medications are processed by the same enzyme system in the liver (CYP3A4) and a transport protein (P-gp). Because they compete for these systems, atorvastatin can slow down the breakdown of rivaroxaban, leading to slightly higher levels of the blood thinner in your body.

It is generally safe to take these two medicines together, as the interaction is usually mild. However, you should be vigilant for any signs of unusual bleeding or bruising. If you notice blood in your urine, black tarry stools, or a nosebleed that won't stop, contact your doctor immediately. Ensure your doctor knows you are taking both, especially if your dose of atorvastatin is increased.

Grossesse

Vous ne devez pas prendre de l'atorvastatine si vous êtes enceinte ou prévoyez de le devenir, car cela peut causer des dommages graves à un bébé à naître. Utilisez une contraception efficace pendant que vous prenez ce médicament.

Muscle disorders - atorvastatin

Consultez immédiatement un médecin si vous ressentez des douleurs musculaires inexpliquées, une sensibilité ou une faiblesse. Dans de rares cas, cela peut entraîner une affection grave appelée rhabdomyolyse, qui provoque des lésions rénales.

Active bleeding or high bleeding risk

Rivaroxaban significantly increases your risk of serious bleeding. You must seek immediate medical help if you have a fall or head injury, or if you notice signs of internal bleeding such as black tarry stools or coughing up blood.

Jus de pamplemousse

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcool

While there is no direct interaction, drinking large amounts of alcohol can increase the risk of liver problems with atorvastatin and increase the risk of stomach bleeding with rivaroxaban. It is best to stick to the recommended daily limits.

Food (General) - rivaroxaban

The 15mg and 20mg tablets must be taken with food to ensure the medicine is absorbed properly into your body. If taken on an empty stomach, the medicine may not work as well. The 2.5mg and 10mg doses can be taken with or without food.

Taking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.