Puis-je prendre du cannabis et de la clozapine ensemble ?

Pourquoi cela se produit

Cannabis smoke contains chemicals (hydrocarbons) that speed up the liver enzymes responsible for breaking down clozapine. This can lower the amount of medicine in your system. Conversely, if you stop smoking, the levels can rise rapidly. Additionally, both substances affect the central nervous system and heart rate, leading to 'additive' effects where the side effects of both are intensified.

You must speak with your doctor or psychiatrist before using cannabis or if you plan to change your current usage habits. Your doctor will likely need to perform more frequent blood tests to monitor your clozapine levels and may need to adjust your dose. Do not stop or start using cannabis abruptly without medical supervision.

Infection or flu-like symptoms

You must have regular blood tests because clozapine can cause a dangerous drop in white blood cells (agranulocytosis). Contact your doctor immediately if you develop a sore throat, fever, or any signs of infection.

Smoking status changes

If you stop or start smoking tobacco, you must tell your doctor immediately. Tobacco smoke changes how your body breaks down clozapine; stopping smoking can cause clozapine levels to rise to toxic, dangerous levels.

Myocarditis (heart muscle inflammation)

Clozapine carries a risk of serious heart inflammation, especially in the first two months. Contact your doctor immediately if you experience a persistent fast heartbeat at rest, chest pain, or shortness of breath.

Constipation

Clozapine can severely slow down your bowels (paralytic ileus), which can be fatal. You must tell your doctor if you become constipated or have not had a bowel movement for more than two days.

Psychose ou Schizophrénie

Vous ne devez pas consommer de cannabis si vous avez des antécédents personnels ou familiaux marqués de schizophrénie ou d'autres troubles psychotiques, car cela peut déclencher ou aggraver ces conditions.

Conduite et utilisation de machines

C'est une infraction de conduire si votre capacité est altérée par le cannabis. Même si vous ne vous sentez pas « défoncé », la drogue reste dans votre système et peut entraîner une condamnation pour conduite sous l'influence de drogues.

Caffeine (Coffee, Tea, Cola, Energy drinks)

Caffeine can significantly increase the levels of clozapine in your blood, which may increase the risk of side effects. If you suddenly stop drinking caffeine, your clozapine levels may drop, making the medicine less effective. Try to keep your caffeine intake consistent and talk to your doctor before making any major changes.

Alcool

Alcohol can increase the sedative effects of both clozapine and cannabis, making you feel very sleepy, dizzy, or confused. It can also increase the risk of falls and impair your coordination. It is best to avoid alcohol while taking these medicines.

Jus de pamplemousse

Grapefruit juice can interfere with how your body breaks down certain compounds in cannabis (like CBD and THC). This may increase the levels of the medicine in your blood and lead to more side effects.

Repas riches en graisses

Eating a meal high in fat (such as a cooked breakfast or fast food) just before or after taking oral cannabis can significantly increase the amount of the medicine absorbed by your body. This may lead to stronger or more unpredictable effects.

Taking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.