Can I take Clarithromycin and Paracetamol together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known interaction between clarithromycin and paracetamol. It is generally safe to take these two medicines together.
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Why this happens
These two drugs are processed by different pathways in the body. Clarithromycin is primarily broken down by a specific liver enzyme (CYP3A4) which it also inhibits, while paracetamol is processed through different liver pathways (glucuronidation and sulfation). Because they do not compete for the same 'machinery' in the liver, they do not interfere with each other.
What you should do
You can take paracetamol while you are on a course of clarithromycin. Always follow the dosage instructions on the packet for paracetamol and complete the full course of your antibiotic as prescribed by your doctor. If you feel unwell or develop a rash, contact your healthcare provider.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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