Can I take Co-codamol and Mirtazapine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking co-codamol and mirtazapine together can make you feel very sleepy, dizzy, and confused. It may also slow down your breathing or cause constipation.
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Why this happens
Both medicines affect the central nervous system (the brain). Co-codamol contains codeine (an opioid) and mirtazapine is an antidepressant; both have sedative effects. When taken together, these effects add up (an 'additive effect'), making the side effects of both drugs much stronger.
What you should do
Use this combination with caution. Do not drive, operate machinery, or perform tasks that require you to be alert until you know how these medicines affect you. Avoid drinking alcohol, as this will make the sleepiness much worse. If you feel extremely drowsy or have difficulty breathing, seek medical help immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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