Puis-je prendre Empagliflozine et Rybelsus ensemble ?
Guide d'interaction médicamenteuse
Publié à l'origine 25 janv. 2026
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Taking these two medicines together can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). You may also have a higher risk of becoming dehydrated or experiencing a rare but serious condition called ketoacidosis.
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Pourquoi cela se produit
Both medicines work to lower blood sugar but in different ways. Empagliflozin (Jardiance) makes you pass sugar out through your urine, while Rybelsus (semaglutide) helps your body release more insulin. Because they both lower blood sugar, their combined effect is much stronger. Additionally, empagliflozin is a diuretic (water pill) effect, which can lead to fluid loss.
Ce que vous devriez faire
Retour au sommaireYou should only take these together if prescribed by your doctor. Monitor your blood sugar levels regularly. Learn to recognise signs of 'hypos' (such as shaking, sweating, or confusion) and keep a fast-acting sugar source nearby. Ensure you drink plenty of water to stay hydrated. If you feel very unwell, nauseated, or have stomach pain, contact your doctor immediately.
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Précautions importantes
Retour au sommaireDehydration and Diabetic Ketoacidosis (DKA)
You must stop taking empagliflozin and seek urgent medical help if you become very unwell, lose your appetite, or have persistent vomiting/diarrhoea. This is to prevent a rare but serious condition called ketoacidosis, which can occur even if your blood sugar levels are normal.
Pancréatite
Stop taking Rybelsus and contact your doctor immediately if you experience severe, persistent stomach pain that may radiate to your back, as this can be a sign of an inflamed pancreas (pancreatitis).
Fournier’s gangrene - empagliflozin
Seek immediate medical attention if you experience severe pain, tenderness, redness, or swelling in the genital or anal area, accompanied by fever or a general feeling of being unwell.
Foot ulcers
Check your feet regularly and tell your doctor immediately if you develop any sores, ulcers, or infections, as empagliflozin may increase the risk of lower limb amputations if foot care is neglected.
Diabetic retinopathy - Rybelsus
If you have diabetic eye disease, tell your doctor immediately if you notice any changes in your vision during treatment, as rapid improvements in blood sugar can temporarily worsen this condition.
Avertissements sur la nourriture et les boissons
Retour au sommaireAlcool
It is best to avoid or strictly limit alcohol while taking these medicines. Alcohol can interfere with blood sugar control and increases the risk of a serious condition called ketoacidosis (with empagliflozin) or low blood sugar (hypoglycaemia). Drinking alcohol can also increase the risk of inflammation of the pancreas (pancreatitis) when taking Rybelsus.
Water and fluids
It is essential to drink plenty of water and stay well-hydrated. Empagliflozin works by removing sugar through your urine, which increases the amount of fluid you lose. This can lead to dehydration and low blood pressure if you do not drink enough fluids.
Food and drink (general)
Rybelsus must be taken on an empty stomach. You should wait at least 30 minutes after taking your tablet before having your first food, drink (other than plain water), or other oral medicines. If you eat or drink too soon, the medicine will not be absorbed properly and will not work.
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Utilisation d'autres médicaments
Retour au sommaireTaking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Avertissement
Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
25 janv. 2026 | Publié à l'origine

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