Can I take Colecalciferol and Prednisolone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking prednisolone can lower the levels of vitamin D (colecalciferol) in your body, making the vitamin D supplement less effective. Over time, this can lead to weaker bones.
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Why this happens
Prednisolone is a steroid medication that interferes with how your body processes vitamin D. It can speed up the breakdown of vitamin D and also reduce how much calcium your body absorbs from your food, which vitamin D normally helps with.
What you should do
You can take these medicines together, but your doctor may need to monitor your vitamin D and calcium levels with blood tests. In some cases, a higher dose of colecalciferol or an additional calcium supplement may be recommended to protect your bone health while you are taking steroids.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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