Can I take Ibuprofen gel 10% and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
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Using ibuprofen gel alongside Shortec (oxycodone) is generally safe, but there is a small risk of increased side effects such as drowsiness, dizziness, or stomach irritation if the ibuprofen is absorbed into the bloodstream in significant amounts.
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Why this happens
Shortec is an opioid painkiller that affects the central nervous system, while ibuprofen is an anti-inflammatory. While the gel is applied to the skin to limit its effects to one area, some of it can still enter the bloodstream. If this happens, it may slightly increase the risk of stomach upset or kidney strain when combined with other strong medications.
What you should do
You can use these two medications together. To stay safe, apply the ibuprofen gel only to the specific area that hurts and do not use more than the amount recommended on the packaging. If you feel unusually sleepy, dizzy, or develop stomach pain, stop using the gel and speak to your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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